Primary Haemangiopericytoma in the Pelvic Cavity of a Dog

Abstract

A 9-year-old female Yorkshire terrier with lameness of the hind leg was examined at the local animal hospital in Gwangju, Republic of Korea on March, 2004. The radiological findings revealed a mass between the urinary bladder and cervix of the uterus. The encapsulated pelvic mass, measuring 4.0 x 3.0 x 2.5 cm was surgically removed. Grossly, the mass was white and firm and microscopically showed a perivascular whorled pattern of spindle cells. By immunohistochemistry, tumour cells tested positive for vimentin and alpha-smooth muscle actin, and negative for desmin, S-100, lysozyme and cytokeratin. The tumour was diagnosed both histologically and immunohistochemically as a haemangiopericytoma. There were no signs of recurrence within 12 months after surgery. This is the first case report of a haemangiopericytoma in the pelvic cavity of a dog.

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

“…Leiomyosarcomas arise from smooth muscles situated anywhere in the body, and the tumour cells have centrally located and characteristic cigar-shaped nuclei (Kapatkin et al 1992;Maas et al 2007). Hemangiopericytomas are characterised by spindle cells containing cytoplasmic processes arranged in whorls around blood vessels with a fingerprint pattern formed by neoplastic cells (Xu 1986;Cho and Park 2006). Schwannomas and neurofibrosarcomas are characterised by interwoven bundles of small wavy spindle cells with occasional palisading and whorls and they have positive reactions to S-100 protein, GFAP and NSE (Pumarola et al 1996;Cullen et al 2002;Hesaraki et al 2010).…”

“…During the diagnostic process, fibrosarcomas must be distinguished from other types of malignant tumours including leiomyosarcomas, hemangiopericytomas, and schmannomas and neurofibrosarcomas (Xu 1986;Kapatkin et al 1992;Goldschmidt and Hendrick 2002;Cho and Park 2006;Maas et al 2007). Leiomyosarcomas arise from smooth muscles situated anywhere in the body, and the tumour cells have centrally located and characteristic cigar-shaped nuclei (Kapatkin et al 1992;Maas et al 2007).…”

Primary pulmonary spindle cell tumour (haemangiopericytoma) in a dog

“…The most common location of this neoplasm is on the thigh or retroperitoneum in human beings and cutaneous or subcutaneous tissue of the limbs in dogs (Kuntz and others 1997, Pandey and others 1997, Mazzei and others 2002). Uncommon sites of haemangiopericytomas described in dogs include the orbit (Beltran and others 2001), the spleen (Obwolo 1986) and the pelvic cavity (Cho and Park 2006).…”

Perivascular Wall Tumor in the Brain of a Dog

“…In a study of 20 canine cutaneous perivascular wall tumors, all tumors were intensely vimentin positive and negative for CD18, factor VIII-related antigen, GFAP, and S-100 [2]. Case reports of canine hemangiopericytomas occurring outside the skin and subcutis have also stained positive for vimentin and negative for S-100 [6,9]. As there are no specific immunohistochemical markers for perivascular wall tumors, a diagnosis is based on histopathologic appearance in combination with immunohistochemistry findings [2].…”

“…Hemangiopericytomas and other perivascular wall tumors most commonly occur in the skin and subcutis of dogs [4,5]. However, there have been reports of primary hemangiopericytomas and perivascular wall tumors in the lung [6], orbit [7], spleen [8], pelvic cavity [9], mesentery [10], nasal cavity [11], frontal sinus [12], and nasopharynx of dogs [13].…”