Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Abstract

An 11-year-old male Cocker Spaniel was examined for a palpable abdominal mass located in the jejunum after presenting with a history of anorexia and constipation for several weeks. In a contrast radiogram, a structure with well-defined borders adjacent to the intestine was determined. The intestinal mass, measuring 16 × 9.19 × 8.6 cm and weighing 900 g was surgically removed. At gross examination, when the lumen of a portion of the intestine excised together with the tumour mass was exposed, an ulcerated, oval-shaped area 1.2 × 0.6 cm in size was observed on the mucosa. The outer surface of the tumour was homogenous and expanded outwards from the intestinal wall. Histologically, the tumour was composed of fusiform-elongated spindle-shaped to polygonal neoplastic cells forming interlacing fascicles or interwoven bundles in an atypical herringbone pattern. Immnunohistochemically, neoplastic cells stained intensely positive for vimentin, and negative for α-SMA, desmin, cyotokeratin (AE1/AE3), S-100 protein, glial fibrillary acidic protein, neuron specific enolase and synaptophsin. On the basis of the histopathological and immunohistochemical results, the tumour was diagnosed as a fibrosarcoma. The present report is a very rare description of fibrosarcoma of the dog intestine associated with intestinal perforation.

Histopathological and Immunohistochemical Diagnosis of Canine Fibrosarcoma

“…As in our case, skin and subcutis have been reported as the primary sites of occurrence of fibrosarcomas in dogs and other domestic animals by Goldschmidt and Hendrick (2002). However Avci et al, (2012) has reported a rare case of intestinal fibrosarcoma in a 11 year old Cocker Spaniel dog. The numerous mitotic figures seen in microscopic examination were highly suggestive of the malignant nature of the tumour.…”

Fibrosarcoma en ovinos de la zona altiplánica del Perú: reporte de casos

“…In order to interpret the macroscopic characteristics A mesenteric lymph node near this node was found to be very swollen, pale in color, resistant to cutting, with a similar appearance to the original node, and surrounded by a jelly-like substance (figure 3). reported tumors of this type located on the lips, gums, maxilla, and cornea in alpacas and llamas; some other cases of this malignant tumor may be located in deep soft tissues or near the bones 10 , in the genital organs such as the vulva or vagina 23 or in any other part of the body 8,9,16,20 .…”