Congenital occurrence of solitary infantile myofibromatosis of the spleen

Abstract

Infantile myofibromatosis (IM) is a rare soft tissue tumor of infancy and childhood. We report the case of a newborn girl with an abdominal tumor discovered at 32 weeks of gestation by fetal ultrasound. She underwent a laparotomy for an unexplained abdominal mass 20 days after birth. The tumor originated from the spleen and was removed by splenectomy. There were no other abnormal findings on diagnostic modalities. Based on the histological examinations, the tumor was diagnosed as an IM. Although extremely rare during the neonatal period, solitary type IM should be considered as a differential diagnosis of the splenic tumor.

Prenatally Diagnosed Infantile Myofibroma of Sartorius Muscle—A Differential for Soft Tissue Masses in Early Infancy

“…Clinically, a firm or hard nodule in the skin, subcutaneous tissue, muscle, or bone is defined as the solitary form, which is the most common (50–75% of cases), as noted by Chung and Muraoka, being the form of presentation in our patient [ 8 , 20 ]. The single nodules of myofibroma are usually well circumscribed, with an initial phase of rapid growth, and painless [ 9 ].…”

Prenatal sonography of multicentric infantile myofibromatosis: Case report and review of the literature

“…Although IM is the most common fibrous tumor of infancy, there have been very few cases diagnosed prenatally (Table ) . According to Meizner et al, the incidence of soft tissue tumors in newborns has been estimated to be 1/150,000 live births, with IM being the most common nonvascular tumor of infancy .…”

Prenatal diagnosis of infantile myofibromatosis of the lung: A case report and review of the literature

“…Although the twin with IM died from sepsis 12 days after birth, the co‐twin developed uneventfully. Muraoka et al detected a splenic mass that was treated with splenectomy on the 20th day after birth and Kubota et al detected a left upper arm mass, which was treated with radical resection of the tumor at 2 months of age. The other cases that were detected prenatally were by Meizner et al and Nishioka et al…”