Prenatal diagnosis of infantile myofibromatosis of the lung: A case report and review of the literature

Abstract

We present a case of infantile myofibromatosis of the lung detected at 32 weeks' gestation. The fetus was monitored with weekly ultrasound examinations measuring the mass size and amniotic fluid index. On day 2 after delivery, due to respiratory distress, an exploratory thoracotomy was undertaken and the mass was resected.

Prenatal sonography of multicentric infantile myofibromatosis: Case report and review of the literature

“…There have been reports of extensive lung involvement necessitating radical surgical excision. 6 In conclusion, we have described a case of IM that is rarely diagnosed prenatally. IM should be considered in the differential diagnosis of soft tissue masses diagnosed prenatally and in the neonatal period.…”

“…Although IM is the most common fibrous tumor of infancy, there have been very few cases diagnosed prenatally (Table ) . According to Meizner et al, the incidence of soft tissue tumors in newborns has been estimated to be 1/150,000 live births, with IM being the most common nonvascular tumor of infancy .…”

“…In IM with visceral involvement, options for management include interferon‐alpha treatment, chemotherapy, radiation, and surgical excision. There have been reports of extensive lung involvement necessitating radical surgical excision …”

Diagnosis of infantile myofibromatosis with pseudo-ulcerated plaque using prenatal ultrasound: A case report

“…By contrast, the multicentric form of IM widely invades subcutaneous muscles, bones and viscera (1,19,20). Both solitary and multicentric forms of IM are associated with poor prognosis if they affect viscera, particularly the heart, the lungs and gastrointestinal tracts (9,13,18). Ultrasound imaging characteristics of IM include stiffness, encapsulation, calcification, liquefaction and signs of reduced blood flow (4,21).…”

Infantile Myofibromatosis

“…A solid paraspinal mass (Meizner et al 2000) 6. A mass on the lung parenchyma (Yeniel et al 2013) vincristine, adriamycin-D, and cyclophosphamide produces regression of fibromatosis in some children with recurrent or unresectable lesions (Raney et al 1987). 3.…”