Spindle cell oncocytoma of the adenohypophysis in a woman: a case report and review of the literature

Abstract

IntroductionSpindle cell oncocytoma of the adenohypophysis is a rare tumour recently reported by Roncaroli et al. in 2002. This tumour is considered a grade I tumour by the World Health Organization.Case presentationWe describe what is, to the best of our knowledge, the 14th case of its kind in the literature. A 45-year-old African woman presented clinical and radiological findings related to a nonfunctioning pituitary adenoma. The diagnosis was made on the basis of histological and immunohistochemical findings.ConclusionThe purpose of this work is to report a rare pituitary tumour and to describe its histological and immunohistochemical features, which were characterized by the expression of thyroid transcription factor 1 antigen by tumour cells. This fact could support the theory of a possible common origin of these tumours in pituicytomas. In fact, thyroid transcription factor 1 is considered to be a specific marker of pituicytes.

Update on Hypophysitis and TTF‐1 Expressing Sellar Region Masses

“…It had first been reported as a distinct entity by Roncaroli in 2002, in five patients culled from four different institutions, reflecting the rarity of the entity (90). Even with these five initial examples, only approximately 20 total cases have been published (2,8,26,37,56,75,88,102,117,118). All have occurred in adults thus far, with a mean of 56 years (38).…”

An Unusual Oncocytic Sellar Neoplasm in a Patient with Birt-Hogg-Dubé Syndrome

“…More recently, TTF-1 nuclear positivity has also been described in SCO (Lee, Tihan, Scheithauer, Zhang, & Gonatas, 2009;Mlika et al, 2011;Ogiwara et al, 2011;; however this is not specific to SCO as TTF-1 is also expressed in other primary brain tumors, and generally those arising in the sellar and third ventricular regions (Kristensen, Nielsen, & Vyberg, 2011;Lee et al, 2009;Zamecnik, Chanova, & Kodet, 2004). It is important to note that these studies have described variable expression of TTF-1 in SCO and other primary brain tumors with both the SPT24 and the 8G7G3/1 clones; in general if positive, the SPT24 clone tends to show stronger expression than the 8G7G3/1 clone.…”

“…Spindle cell oncocytoma of the adenohypophysis is a rare and diagnostically challenging entity with only twenty-four cases reported in the English literature since the first account in 2002 by Roncaroli et al, (Alexandrescu, Brown, Tandon, & Bhattacharjee, 2012;Borges, Lillehei, & KleinschmidtDeMasters, 2011;Borota et al, 2009;Coire, Horvath, Smyth, & Kovacs, 2009;Dahiya et al, 2005;Demssie et al, 2011;Farooq, Bhatt, & Chang, 2008;Fujisawa et al, 2012;Fuller, Scheithauer, Roncaroli, & Wesseling P, 2007;Kloub, Perry, Tu, Lipper, & Lopes, 2005;Matyja et al, 2010;Mlika et al, 2011;Ogiwara, Dubner, Shafizadeh, Raizer, & Chandler, 2011;Romero-Rojas et al, 2011;Roncaroli et al, 2002;Singh et al, 2012;Vajtai, Sahli, & Kappeler, 2006). The classical histologic description of SCO is that of a fascicular neoplasm arising from the adenohypophysis and composed of spindled and epithelial oncocytic cells with immunohistochemical positivity for S100, vimentin, EMA, galectin-3, and antimitochondrial antibodies (Roncaroli et al, 2002).…”

Spindle cell oncocytoma of adenohypophysis: Review of literature and report of another recurrent case

“…SCO is a rare entity, described first in 2002 with few subsequent case reports to date . As described first by Roncaroli et al , SCO occurs most commonly in middle and older age groups with mean age of 61.6 years .…”