Sarcoidosis is a multisystem disease of unknown cause and with a worldwide distribution. Involvement of the central nervous system occurs in a relatively small number of patients with sarcoidosis. Isolated neurosarcoidosis without signs of systemic disease however is a rare. In this report, we present an unusual case of neurosarcoidosis with intra cranial mass mimicking radiologically a glioma. Pathological examination revealed intraparenchymatous necrotising granulomatous lesions. After clinicopathological correlation, the diagnosis of a necrotizing cerebral granulomatosis (neurosarcoidosis) with atypical systemic involvement was made. Because of its non-specific clinical presentation and neuroradiological imaging characteristics, intracranial neurosarcoidosis remains a very difficult diagnosis, particularly in the absence of systemic signs of the disease.
IntroductionSpindle cell oncocytoma of the adenohypophysis is a rare tumour recently reported by Roncaroli et al. in 2002. This tumour is considered a grade I tumour by the World Health Organization.Case presentationWe describe what is, to the best of our knowledge, the 14th case of its kind in the literature. A 45-year-old African woman presented clinical and radiological findings related to a nonfunctioning pituitary adenoma. The diagnosis was made on the basis of histological and immunohistochemical findings.ConclusionThe purpose of this work is to report a rare pituitary tumour and to describe its histological and immunohistochemical features, which were characterized by the expression of thyroid transcription factor 1 antigen by tumour cells. This fact could support the theory of a possible common origin of these tumours in pituicytomas. In fact, thyroid transcription factor 1 is considered to be a specific marker of pituicytes.
Malignant trichoblastoma or trichoblastic carcinoma is an entity recently individualized arising in trichoblastoma; it refers to a malignant epithelial proliferation originating from adnexal structures, with morphological characters that remind in some cases a trichoepithelioma; in other cases, it can appear like a basocellular carcinoma or a sebaceous carcinoma. We report the case of a 56-year-old patient having undergone a medical visit for the occurrence, 2 years earlier, of a 2 cm retroauricular ulcerative nodule, and numerous other nodules of less than 1 cm and translucent, localized in the region of the scalp and forehead. The patient underwent biopsies of one of the small nodules and the tumor that showed in terms of histology an aspect of trichoepithelioma and a malignant trichoblastoma developed on a trichoepithelioma. A surgical excision of the tumor had been made, with an IMRE plastid and a transplantation of a free flap of scalp skin. Pathological findings demonstrated a temporal and parietal trichoblastic carcinoma of the scalp, with healthy excised limits. The clinicopathological profile, the histogenesis, and the difficulties related to histopathological diagnosis and treatment of this rare and new entity are discussed.
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