Spindle cell oncocytoma of adenohypophysis: Review of literature and report of another recurrent case

Abstract

Spindle cell oncocytoma (SCO) of adenohypophysis was first described in 2002 by Roncaroli et al. as a new entity in the tumors originating from adenohypophysis. It was subsequently recognized as a distinct entity in the 2007 WHO classification of CNS tumors and retained in the current updated classification. In contrast to that suggested by the original authors, this tumor does have a potential for recurrence as first described by Kloub et al. and later with many such case reports. This tumor can be confused with other sellar tumors like pituicytomas and pituitary adenoma, both radiologically and histopathologically. However, it is imperative to differentiate these tumors from the above-mentioned differential diagnoses as it certainly has a recurrent potential. To date only 34 cases of SCO have been published in the English literature. Herein we present a rare SCO case with unusually aggressive course in a 64-year-old man, which recurred 4 years after the initial diagnosis.

Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features

“…Because of the compressive effect on the optic chiasm and pituitary gland, the common symptoms include visual disturbances, headache, and panhypopituitarism. Histologically, the tumor is composed of spindle cells arranged in interlacing fascicular structures with intervening blood vessels and should be differentiated with null cell adenoma with oncocytic change, meningioma, schwannoma, granular cell tumor, solitary fibrous tumor, and paraganglioma [8]. Immunohistochemically, SCO is negative for neuroendocrine markers such as synaptophysin and chromogranin, pituitary hormones, cytokeratin, desmin, and smooth muscle actin and typically positive for TTF-1, EMA, vimentin, and galectin-3 [1,[3][4][5][6].…”

A rare case report of pituicytoma with biphasic pattern and admixed with scattered Herring bodies

“…Mitochondrion-rich cells usually show apparent eosinophilic cytoplasm, such as Hürthle cell [6], and gastric parietal cells [7]. Moreover, there is evidence that most of SCO are positive for epithelial membrane antigen and Galectin-3 [8]. In this case, the tumour cells are negative for the three markers and lack apparent eosinophilic cytoplasm, so the diagnosis of pituicytoma is appropriate.…”

Posterior pituitary tumours: patient outcomes and determinants of disease recurrence or persistence

“…Surgery is the treatment of choice for symptomatic PPT usually by the transsphenoidal route (TSS). However, PPTs, including both pituicytomas and SCOs, often show recurrence/persistence following surgery ( 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ).…”