Spinal leptomeningeal metastases following glioblastoma multiforme treated with radiotherapy

Lindsay, Andrew; Holthouse, David; Robbins, Peter A.; Knuckey, Neville W.

doi:10.1054/jocn.2002.1079

Cited by 31 publications

(25 citation statements)

References 3 publications

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“…In these 23 reports, 42 separate cases were described; treatment and outcome data were available in 35 of these cases (Table 1). 1,2,5,7,10,11,13,20,26,32,35,36,38,39,46,48,58,60,66,68,70,74,77 From these cases we quantitatively evaluated the presentation trends, as reported in the text and associated tables.…”

Section: Methodsmentioning

confidence: 99%

“…35,48,77 Despite the lack of consensus regarding optimal management of spinal cord metastases, several strategies with varying degrees of success have been documented. Possible treatment options have included external beam radiation therapy (25-60 Gy in 2.5-Gy fractions), 1,5,26,39,46,48,58,60 decompressive surgery (confirmation of diagnosis, pain management), 5,35,36,58,70 intravenous or intrathecal chemotherapy, 5,26,35,36,39,48 corticosteroids and opiates, 1 and prevention of CSF dissemination (stereotactic biopsy, cranial radiotherapy, and delayed tumor resection). 77 Radiotherapeutic treatment of the entire craniospinal axis has also been suggested.…”

Section: Prognosis and Treatmentmentioning

confidence: 99%

“…Nevertheless, radiation therapy was the most widely used intervention. In one of the longest surviving cases, Lindsay et al 48 treated a patient with radiation therapy (1 dose at 8 Gy) and chemotherapy (3 cycles of lomustine), and the patient survived 12 months after the diagnosis of a thoracic spinal metastasis. Onda et al 58 treated a patient with cervical metastasis using a laminectomy for decompression followed by radiation therapy, resulting in 12 months of survival after metastasis diagnosis.…”

Section: Prognosis and Treatmentmentioning

confidence: 99%

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Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Lawton

Nagasawa

Yang

et al. 2012

SPI

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Glioblastoma multiforme (GBM) is one of the most common and aggressive primary brain tumors, composing 12%–20% of all intracranial tumors in adults. Average life expectancy is merely 12–14 months following initial diagnosis. Patients with this neoplasm have one of the worst 5-year survival rates among all cancers despite aggressive multimodal treatment consisting of maximal tumor resection, radiation therapy, and adjuvant chemotherapy. With recent advancements in management strategies, there has been improvement in the overall trend in patient outcomes; however, recurrence remains nearly inevitable. While most tumors recur locally, metastases to distal locations have become more common. Specifically, the last decade has seen an increased incidence of spinal metastases, representing an emerging complication in patients with intracranial GBM. However, the literature regarding prevention strategies and the presentation of spinal metastases has remained scarce. As local control of primary lesions continues to improve, more cases of spinal metastases are likely to be seen. In this review the authors present a new case of metastatic GBM to the L-5 nerve root, and they summarize previous cases of intracranial GBM with leptomeningeal spinal metastatic disease. They also characterize key features of this disease presentation and discuss areas of future investigation necessary for enhanced prevention and treatment of this complication.

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Section: Methodsmentioning

confidence: 99%

Section: Prognosis and Treatmentmentioning

confidence: 99%

Section: Prognosis and Treatmentmentioning

confidence: 99%

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Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Lawton

Nagasawa

Yang

et al. 2012

SPI

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“…The main parameters associated with long-term survival are younger age (<40 years), good performance status, and the ability to undergo gross total resection, followed by radiotherapy and chemotherapy [2, 10, 13]. GBM can easily metastasize within the neuroaxis (i.e., the meninges or spinal cord) via the CSF occurring in approximately 20% of GBM patients [14]. GBM metastases outside the central nervous system are rare [15], but may be found in the extraocular muscles, limbus, or orbit [16, 17].…”

Section: Discussionmentioning

confidence: 99%

Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review

Lin

Huang

2017

BMC Ophthalmol

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BackgroundMalignant optic gliomas are rare, but they rapidly become lethal visual pathway tumors. We present the clinical course, treatment, and prognosis of a case of unilateral malignant optic glioma in a young man with a history of brain glioblastoma multiforme (GBM).Case presentationA 21-year-old man, who had GBM 7 years ago complained of a transient shadow in his vision and presented with normal visual acuity but optic disc edema and an enlarged blind spot in the right eye (oculus dexter, OD). Magnetic resonance imaging (MRI) showed a right intraorbital optic nerve tumor without a brain lesion. Chiasm involvement and severe vision deterioration occurred 3 months later. A biopsy of the right optic nerve revealed glioblastoma. Concurrent chemoradiotherapy (CCRT) prevented involvement of the fellow eye 1 year after symptom onset.ConclusionThis report demonstrated that a regular ocular exam should be recommended for several years after GBM. In young healthy patients who are able to undergo chemotherapy and radiotherapy, visual function in the fellow eye can be preserved.

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“…Our patient corroborates the literature with symptomatic spinal metastases more commonly occurring in younger patients, as in Table 1. [11][12][13][14] As for treatment of spinal drop metastases, different options include resection if the lesions can be localized. Steroids and focal radiotherapy have been used, with little clinical benefit.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Management of Spinal Metastasis of Glioblastoma

Tai¹,

Dubey

Salim³

et al. 2015

Can. J. Neurol. Sci.

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Spinal leptomeningeal metastases following glioblastoma multiforme treated with radiotherapy

Cited by 31 publications

References 3 publications

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review

Diagnosis and Management of Spinal Metastasis of Glioblastoma

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