Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review

Abstract

BackgroundMalignant optic gliomas are rare, but they rapidly become lethal visual pathway tumors. We present the clinical course, treatment, and prognosis of a case of unilateral malignant optic glioma in a young man with a history of brain glioblastoma multiforme (GBM).Case presentationA 21-year-old man, who had GBM 7 years ago complained of a transient shadow in his vision and presented with normal visual acuity but optic disc edema and an enlarged blind spot in the right eye (oculus dexter, OD). Magnetic resonance imaging (MRI) showed a right intraorbital optic nerve tumor without a brain lesion. Chiasm involvement and severe vision deterioration occurred 3 months later. A biopsy of the right optic nerve revealed glioblastoma. Concurrent chemoradiotherapy (CCRT) prevented involvement of the fellow eye 1 year after symptom onset.ConclusionThis report demonstrated that a regular ocular exam should be recommended for several years after GBM. In young healthy patients who are able to undergo chemotherapy and radiotherapy, visual function in the fellow eye can be preserved.

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“…5C ). Glioma may affect the optic nerve (optic nerve glioma), which is the most common primary neoplasm of the optic nerve 92 . Retinal imaging traits also had shared genetic effects with migraine/headache 93 in 5 regions and cerebrovascular diseases in 9 regions, including stroke 94 , Moyamoya disease 95 , intracranial aneurysm 96 , and cerebral aneurysm 97 ( Figs.…”

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“…2017 [30] 66/M 12 mo Meningioma T1 + contrast (Enhancement) Surgical resection and CT 16 mo Lin et al. [31] 21/M 4 mo Optic neuritis T1 + contrast (Enhancement) Srugical resection and CT - Alabiad et al. 2020 [29] 18/F 4 wk Unknown T1 + contrast (Enhancement) Surgical resection, CT and RT Alive (>7 y) Current case 77/ M 3 mo Optic neuritis T1 + contrast (Enhancement) T2 (Hyperintense) None 4 mo Wabbels et al.…”

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