Spinal cord and brain glioblastoma multiforme without previous craniotomy

Rivero-Garvía, Mónica; Boto, G.R.; Pérez-Zamarrón, A.; Gutiérrez-González, Raquel; Ahmad, Issa Subhi Issa; Martínez, Armando

doi:10.3171/spi/2008/8/6/601

Cited by 7 publications

(8 citation statements)

References 4 publications

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“…There are fewer articles reporting spinal metastasis in patients without previous brain surgery or radiation therapy 6,8 compared to a number of cases describing patients with spinal metastasis after cranial operation or irradiation. This supports the thesis that surgical manipulation or radiation therapy can alter the blood-brain barrier and spread the tumor cells by hematogenous dissemination and directly through the subarachnoid space 8,14 . However, another study shows that the contact of the intracranial tumor with the CSF due to opening of the ventricles during surgery or due to the primary tumor location seems not to be a precondition for dissemination of the gliomas 3 .…”

Section: Discussionmentioning

confidence: 99%

“…These may include focal back pain, radicular pain, numbness, paraparesis, tetraparesis, sphincter dysfunction, and others symptoms referable to the intracranial tumors such headache, seizures and nausea. Awareness of this symptomatology is important to neurosurgeons, oncologist and clinicians who treat high grade gliomas 4,5,8 . In brazilian literature there are very few publications concerning spinal cord metastatic glioblastoma multiforme.…”

Section: Discussionmentioning

confidence: 99%

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Symptomatic spinal cord metastasis of glioblastoma multiforme

Andrade¹,

Freitas²,

Montanaro³

2018

jbnc

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Palavras Chave: glioblastoma multiforme, metástase espinhal sintomática, região lombar. ABSTRACTSymptomatic spinal cord metastasis from glioblastoma multiforme (GBM) has rarely been reported in the literature. We report the case of a 27-year-old man that presented with back and bilateral leg pain nine months after the primary diagnosis of intracranial GBM. A magnetic resonance imaging (MRI) of the lumbar spine showed a L1-L2 tumor that was removed successfully and histopathological examination was consistent with GBM metastasis. Spinal metastasis should be investigated and included in the differential diagnosis if a patient with a previous history of intracranial GBM presents with spinal symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Symptomatic spinal cord metastasis of glioblastoma multiforme

Andrade¹,

Freitas²,

Montanaro³

2018

jbnc

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“…[ 7 ] However, only 2 cases have been described before with spinal glioblastoma without history of craniotomy or radiotherapy. [ 9 10 ] There are no differences in age at presentation between single or multiple glioblastomas, radiological findings, or biology. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

Multicentric spinal cord and brain glioblastoma without previous craniotomy

et al. 2016

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Background:Glioblastoma multiforme (GBS) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric gliomas lesions are widely separated in site and/or time and its incidence has been reported between 0.15 and 10%. Multicentric gliomas involving supratentorial and infratentorial region are even more rare. In most cases, infratentorial disease is seen after surgical manipulation or radiation therapy and is usually located in the cerebellum or cervical region.Case Report:We present a rare case of symptomatic multicentric glioma in the brain, fourth ventricle, cervical as well as lumbar glioblastoma in an adult without previous therapeutic intervention. We also review the literature of this rare presentation.Conclusions:This report suggests that GBM is a diffuse disease; the more extended the disease, the worse prognosis it has. The management still remains controversial and further studies are required to understand the prognosis factors of dissemination.

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“…There are few articles reporting spinal metastasis in patients without previous brain surgery or radiation therapy 6,8 compared to a number of cases describing patients with spinal metastasis after cranial operation or irradiation. This supports the thesis that surgical manipulation or radiation therapy can alter the blood-brain barrier and spread the tumor cells by hematogenous dissemination or directly through the subarachnoid space 8,14 . However, a study shows that the contact of the intracranial tumor with the CSF by the opening of the ventricles during surgery or just by the primary site of location seems not to be a precondition for dissemination of the gliomas 3 .…”

Section: Case Reportmentioning

confidence: 99%

“…These may include focal back pain, radicular pain, numbness, paraparesis, tetraparesis, sphincter dysfunction, and other symptoms referable to the intracranial tumors such headache, seizures and nausea. Neurosurgeons, oncologist and clinicians who treat high grade gliomas should be aware of such a manifestation 4,5,8 .…”

Section: Case Reportmentioning

confidence: 99%

Symptomatic spinal cord metastasis of glioblastoma multiforme

Andrade¹,

Freitas²,

Montanaro³

2018

jbnc

View full text Add to dashboard Cite

Symptomatic spinal cord metastasis from glioblastoma multiforme (GBM) has rarely been reported in the literature. We report the case of a 27-year-old man who presented with back and bilateral leg pain nine months after the primary diagnosis of intracranial GBM. A magnetic resonance imaging (MRI) of the lumbar spine showed a L1-L2 tumor that was removed successfully and histopathological examination was consistent with GBM metastasis. Spinal metastasis should be investigated and included in the differential diagnosis in a patient with a previous history of intracranial GBM presenting with spinal symptoms.

show abstract

Spinal cord and brain glioblastoma multiforme without previous craniotomy

Cited by 7 publications

References 4 publications

Symptomatic spinal cord metastasis of glioblastoma multiforme

Symptomatic spinal cord metastasis of glioblastoma multiforme

Multicentric spinal cord and brain glioblastoma without previous craniotomy

Symptomatic spinal cord metastasis of glioblastoma multiforme

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