Multicentric spinal cord and brain glioblastoma without previous craniotomy

Eulate-Beramendi, Sayoa Alvarez de; Piña-Batista, K.M.; Rodrigo, Víctor; Torres-Rivas, Hector E; Rial-Basalo, Juan C

doi:10.4103/2152-7806.185785

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…However, we did not identify any virus in the CSF lymphocytes, assuming that the lymphocytes in CSF were likely related to leptomeningeal spread. However, some cases of spinal metastases of intracranial GBM have also been reported with no previous history of cranial or craniospinal radiation ( 5 , 14 , 15 ). The patient in our report also did not undergo previous surgery or radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…H3K27M-mutant tumors are designated as World Health Organization grade IV tumors, regardless of their histological features ( 3 , 4 ). Multicentric (MC) glioblastoma with many infratentorial lesions mainly occurs in patients who have had prior surgical treatment or radiotherapy ( 5 , 6 ). Although related cases or case series have been reported previously, intracranial H3K27M-mutant GBM with spinal lesions before chemoradiotherapy or craniotomy is not common.…”

Section: Introductionmentioning

confidence: 99%

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Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

et al. 2022

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BackgroundGlioblastoma multiforme (GBM) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric (MC) gliomas involve lesions widely separated in space or time, and MC gliomas involving supra- and infratentorial brain regions are rare. In most cases, the infratentorial lesion is seen after surgical manipulation or radiation therapy; it is typically located in the cerebellum or the cervical region, manifesting as metastasis originating from the brain. Besides, venous thromboembolism in brain tumors is usually seen after craniotomy.Case PresentationWe present an uncommon adult case of symptomatic H3K27M-mutant MC glioblastoma simultaneously present in the brain, fourth ventricle, and cervical and lumbar spinal cord regions accompanied by acute pulmonary artery embolism in an adult woman who had not undergone previous therapeutic interventions. We also review the literature on this interesting presentation.ConclusionOur report highlights that clinicians should be alert to the potential alarming presentation of GBM. The incidence of spinal metastasis of cerebral GBM is increasing. Patients with a prior diagnosis of GBM with or without any new onset in the spinal cord should undergo an early MRI of the spinal cord to confirm the diagnosis at an early stage. While management of GBM remains controversial, more research is needed to explore molecular features of GBM further and develop novel targeted therapies for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

et al. 2022

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“…Similar to solitary gliomas, MCG can occur in various parts of the nervous system, including supratentorial ( 11 ), subtentorial and introspinal ( 33 – 35 ). The most common site is supratentorial.…”

Section: Time and Spacementioning

confidence: 99%

Multicentric Glioma: An Ideal Model to Reveal the Mechanism of Glioma

Yan

Dai²,

Mei³

2022

Front. Oncol.

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As a special type of glioma, multicentric glioma provides an ideal pathological model for glioma research. According to the stem-cell-origin theory, multiple lesions of multicentric glioma share the same neuro-oncological origin, both in gene level and in cell level. Although the number of studies focusing on genetic evolution in gliomas with the model of multicentric gliomas were limited, some mutations, including IDH1 mutations, TERTp mutations and PTEN deletions, are found to be at an early stage in the process of genetic aberrance during glioma evolution based on the results of these studies. This article reviews the clinical reports and genetic studies of multicentric glioma, and intends to explain the various clinical phenomena of multicentric glioma from the perspective of genetic aberrance accumulation and tumor cell evolution. The malignant degree of a glioma is determined by both the tumorigenicity of early mutant genes, and the stemness of early suffered cells.

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“…Glioblastoma multiforme (GBM) is an aggressive primary tumor, which arises from the abnormal astroglial cells in the brain in most cases as well as in the spinal cord in less often cases [ 1 , 2 ]. The incidence of GBM is approximately less than 10 per 100,000 individuals worldwide, and a significant number of the GBM patients show a low survival rate of 14 months or less [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Applications of CRISPR-Cas9 Technology to Genome Editing in Glioblastoma Multiforme

Al-Sammarraie

Ray

2021

Cells

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Glioblastoma multiforme (GBM) is an aggressive malignancy of the brain and spinal cord with a poor life expectancy. The low survivability of GBM patients can be attributed, in part, to its heterogeneity and the presence of multiple genetic alterations causing rapid tumor growth and resistance to conventional therapy. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated (Cas) nuclease 9 (CRISPR-Cas9) system is a cost-effective and reliable gene editing technology, which is widely used in cancer research. It leads to novel discoveries of various oncogenes that regulate autophagy, angiogenesis, and invasion and play important role in pathogenesis of various malignancies, including GBM. In this review article, we first describe the principle and methods of delivery of CRISPR-Cas9 genome editing. Second, we summarize the current knowledge and major applications of CRISPR-Cas9 to identifying and modifying the genetic regulators of the hallmark of GBM. Lastly, we elucidate the major limitations of current CRISPR-Cas9 technology in the GBM field and the future perspectives. CRISPR-Cas9 genome editing aids in identifying novel coding and non-coding transcriptional regulators of the hallmarks of GBM particularly in vitro, while work using in vivo systems requires further investigation.

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Multicentric spinal cord and brain glioblastoma without previous craniotomy

Cited by 6 publications

References 15 publications

Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

Multicentric Glioma: An Ideal Model to Reveal the Mechanism of Glioma

Applications of CRISPR-Cas9 Technology to Genome Editing in Glioblastoma Multiforme

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