Sphygmomanometry-Evoked Allodynia???A Simple Bedside Test Indicative of Fibromyalgia

Vargas, Alfonso; Vargas, Angélica; Hernández-Paz, Roberto; Sánchez-Huerta, Juan Manuel; Romero-Ramírez, Ricardo; Amezcua-Guerra, Luís M.; Kooh, Min; Nava, Arnulfo; Pineda, Carlos; Rodríguez-Leal, Gustavo Arturo; Martı́nez-Lavı́n, Manuel

doi:10.1097/01.rhu.0000249770.86652.3b

Cited by 32 publications

(29 citation statements)

References 6 publications

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“…Patients were identified based on both their responses to a screening survey for CWP (bilateral pain, above/below waist lasting ≥ 1 week in the past 3 months), according to the 4 pain questions of the London Fibromyalgia Epidemiology Study Screening Questionnaire (LFESSQ-4; Table 1 ) [28], and a site visit for physician evaluation of fibromyalgia. During the site visit, physicians completed a tender point exam [29] and blood pressure cuff exam [30], and patients completed the EuroQol 5 dimensions (EQ-5D; Table 1 ) [31]. Physicians at the study sites had completed FM diagnostic training and reported treating at least 10 FM patients on average each month in their practice.…”

Section: Materials and Methodologymentioning

confidence: 99%

Fibromyalgia Outcomes Over Time: Results from a Prospective Observational Study in the United States

Schaefer¹,

Adams²,

Udall³

et al. 2016

TORJ

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Background:Longitudinal research on outcomes of patients with fibromyalgia is limited.Objective:To assess clinician and patient-reported outcomes over time among fibromyalgia patients.Methods:At enrollment (Baseline) and follow-up (approximately 2 years later), consented patients were screened for chronic widespread pain (CWP), attended a physician site visit to determine fibromyalgia status, and completed an online questionnaire assessing pain, sleep, function, health status, productivity, medications, and healthcare resource use.Results:Seventy-six fibromyalgia patients participated at both time points (at Baseline: 86.8% white, 89.5% female, mean age 50.9 years, and mean duration of fibromyalgia 4.1 years). Mean number of tender points at each physician visit was 14.1 and 13.5, respectively; 11 patients no longer screened positive for CWP at follow-up. A majority reported medication use for pain (59.2% at Baseline, 62.0% at Follow-up). The most common medication classes were opioids (32.4%), SSRIs (16.9%), and tramadol (14.1%) at Follow-up. Significant mean changes over time were observed for fibromyalgia symptoms (modified American College of Rheumatology 2010 criteria: 18.4 to 16.9; P=0.004), pain interference with function (Brief Pain Inventory-Short Form: 5.9 to 5.3; P=0.013), and sleep (Medical Outcomes Study-Sleep Scale: 58.3 to 52.7; P=0.004). Patients achieving ≥2 point improvement in pain (14.5%) experienced greater changes in pain interference with function (6.8 to 3.4; P=0.001) and sleep (62.4 to 51.0; P=0.061).Conclusion:Fibromyalgia patients reported high levels of burden at both time points, with few significant changes observed over time. Outcomes were variable among patients over time and were better among those with greater pain improvement.

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Section: Materials and Methodologymentioning

confidence: 99%

Fibromyalgia Outcomes Over Time: Results from a Prospective Observational Study in the United States

Schaefer¹,

Adams²,

Udall³

et al. 2016

TORJ

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“…It has been recommended that the blood pressure cuff be inflated at an approximate rate of 10 mm Hg per second up to 180 mm Hg or to the point at which pain is elicited. Healthy persons usually experience pain when the blood pressure cuff is inflated to 160 mm Hg or more; patients with FM, though, usually experience pain at 100 to 110 mm Hg, or even with less pressure [23]. …”

Section: Methodsmentioning

confidence: 99%

Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate

Fayed¹,

Campayo

Magallón

et al. 2010

Arthritis Res Ther

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IntroductionThe purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables.MethodsTen patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination, DWI, DTI, and proton MRS were performed on the brain areas known to be associated with pain processing.ResultsCompared with healthy controls, FM patients had significantly higher levels of glutamate + glutamine (Glx) (mean ± SD, 10.71 ± 0.50 arbitrary institutional units versus 9.89 ± 1.04; P = 0.049) and higher glutamate + glutamine/creatine (Glx/Cr) ratios (1.90 ± 0.12 versus 1.72 ± 0.23; P = 0.034) in the posterior gyrus. Myoinositol (Ins) levels of the right and left hippocampi were significantly lower in FM patients (4.49 ± 0.74 versus 5.17 ± 0.62; P = 0.008 and 4.91 ± 0.85 versus 6.09 ± 0.78; P = 0.004, respectively). In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Significant correlations between depression, pain, and global function and the posterior gyrus Glx levels and Glx/Cr ratios were observed.ConclusionsGlx within the posterior gyrus could be a pathologic factor in FM. Hippocampal dysfunction may be partially responsible for the depressive symptoms of FM. Additional studies with larger samples are required to confirm these preliminary data.

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“…15 The presence of allodynia was also assessed with a sphygmomanometer following the previously published protocol. 16 Blood pressure cuff is inflated at the rate of 10 mm Hg per second up to 180 mm Hg. The following question is asked to the patient: ''Tell me if the cuff's pressure brings forth pain.''…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Fibromyalgia in Vasovagal Syncope

Vallejo

Martínez-Martínez

Grijalva-Quijada

et al. 2013

Journal of Clinical Rheumatology

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Sphygmomanometry-Evoked Allodynia???A Simple Bedside Test Indicative of Fibromyalgia

Cited by 32 publications

References 6 publications

Fibromyalgia Outcomes Over Time: Results from a Prospective Observational Study in the United States

Fibromyalgia Outcomes Over Time: Results from a Prospective Observational Study in the United States

Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate

Prevalence of Fibromyalgia in Vasovagal Syncope

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