Prevalence of Fibromyalgia in Vasovagal Syncope

Vallejo, Maité; Martínez-Martínez, Laura-Aline; Grijalva-Quijada, Saulo; Olguín-Ruvalcaba, Hector-Manuel; Salas, Elizabeth; Hermosillo, Antonio G.; Cárdenas, Manuel; Martı́nez-Lavı́n, Manuel

doi:10.1097/rhu.0b013e318289bbbb

Cited by 12 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, we did not compile systematic data on the related confounders which may have had an impact on the miRs expression. These confounders may include different phases of menstrual cycle when patients' blood samples were taken and other comorbidities, such as fibromyalgia, since the latter is associated with syncope (43). Fourth, this study is exploratory in nature and is underpowered to demonstrate associations between miR level and a specific headache profile, such as migraine aura.…”

Section: Discussionmentioning

confidence: 99%

Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study

Chen

Liao

et al. 2017

Cephalalgia

View full text Add to dashboard Cite

Background Evidence of vascular dysfunction in migraine is increasing. MicroRNAs (miRs) have emerged as important regulators of vascular endothelial functions. This exploratory study investigated whether circulating levels of miRs associated with endothelial function are altered in migraine patients. Methods Thirty patients with migraine (20-50 years old) without overt vascular risk factors and 30 sex- and age-matched healthy controls participated. The levels of four miRs that regulate endothelial function (miR-155, miR-126, miR-21, and Let-7g) were quantified and expressed in terms of fold changes (2) relative to mean levels in the control group. Associations of miRs levels with headache features and syncope comorbidity were explored. Results Compared to controls, migraine patients had upregulated expression of miR-155 (6.17-fold, p = 0.018), miR-126 (6.17-fold, p = 0.013), and let-7g (7.37-fold, p = 0.005). Levels of miR-155 (r = 0.375, p = 0.041) and miR-126 (r = 0.375, p = 0.041) were associated with syncope frequency in the past year in migraine patients. Migraine patients with aura have insignificant higher expression of miRs levels compared to those without. Conclusions In this pilot study, circulating levels of endothelial-specific miRs appear to be elevated in migraine patients and may be associated with syncope comorbidity.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study

Chen

Liao

et al. 2017

Cephalalgia

View full text Add to dashboard Cite

show abstract

“…In this study, seven additional polymorphisms were included, four of which have participation in cardiovascular physiology 12 and three more SNPs that correlated with fibromyalgia in the Mexican Mestizo population. The reasons behind this choice were 1 the correlation of VVS and ANS dysfunction and the report of the participation of this same dysfunction as a critical element in fibromyalgia 13 , and 2 the description of a positive association of α-AR SNPs with fibromyalgia 14 .…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in B-Adrenergic Receptors Are Associated with Increased Risk to Have a Positive Head-Up Tilt Table Test in Patients with Vasovagal Syncope

Márquez

Fragoso

Pérez-Pérez

et al. 2019

RIC

View full text Add to dashboard Cite

Background: Vasovagal syncope (VVS) is a frequent clinical condition in which a genetic background seems to be implicated. Considering that the adrenergic receptors (ARs) may play a role in VVS, the present study has as principal aim to determine if the αand β-AR (ADRA and ADRB) gene polymorphisms are associated with an increased risk to have a positive head-up tilt table (HUTT) test in patients with VVS. Methods: Nine polymorphisms in the ADRA1A (rs1048101, rs1383914, rs574584, and rs573542), ADRB1 (rs1801252 and rs1801253), ADRB2 (rs1042713 and rs1042714), and ADRB3 (rs4994) genes were analyzed using the 5' exonuclease TaqMan genotyping assay in a group of 134 patients with VVS.

show abstract

“…Main studies are described in detail in the next paragraphs. When a study included more than one technique, it was reported only as the first occurrence Instrumental technique Search string Retrieved and selected records Nerve conduction study (fibromyalgia) AND (nerve conduction studies OR electroneurography) Identified 26 Screened 26 Included 5 [ 6 - 11 ] Laser–nociceptive evoked potential or pain-related evoked potentials (fibromyalgia) AND (laser-evoked potentials or LEP or” nociceptive evoked potentials” or “pain related evoked potentials”) Identified 32 Screened 32 Included 9 [ 3 , 12 - 19 ] Autonomic assessment (fibromyalgia) AND ("sympathetic dysfunction" OR "autonomic assessment" OR "heart rate variability" OR "Quantitative Sudomotor Axon Reflex Test" OR “QSART” OR Valsalva OR Tilt test OR Sudoscan OR "sympathetic skin response" OR "SSR" NOT SSR [journal]) Identified 147 Screened 147 Included 10 [ 20 - 29 ] Skin biopsy (fibromyalgia) AND ("skin biopsy" OR small-fiber neuropathy OR "intraepidermal nerve fiber density" OR IENFD) Identified 99 Screened 99 Included 11 [ 17 , 30 - 39 ] Corneal confocal microscopy (fibromyalgia) AND ("corneal confocal microscopy" OR CCM OR "corneal innervation") Identified 14 Screened 14 Included 5 [ 40 - 44 ] Microneurography (fibromyalgia) AND (microneurography) Identified 5 Screened 5 Included 2 [ 45 , 46 ] Quantitative sensory testing (fibromyalgia) AND (quantitative sensory ...…”

Section: Methodsmentioning

confidence: 99%

Clinical criteria and diagnostic assessment of fibromyalgia: position statement of the Italian Society of Neurology-Neuropathic Pain Study Group

et al. 2023

View full text Add to dashboard Cite

Background The role of central and/or peripheral nervous system dysfunction is basically fundamental in fibromyalgia. Aim The aim of this position statement on behalf of the Neuropathic Pain Study Group of the Italian Society of Neurology is to give practical guidelines for the clinical and instrumental assessment of fibromyalgia (FM) in the neurological clinical practice, taking into consideration recent studies. Methods Criteria for study selection and consideration were original studies, case-controls design, use of standardized methodologies for clinical practice, and FM diagnosis with ACR criteria (2010, 2011, 2016). Results ACR criteria were revised. For diagnostic procedure of small-fiber pathology, 47 studies were totally considered. Recent diagnostic criteria should be applied (ACR, 2016). A rheumatologic visit seems mandatory. The involvement of small fibers should request at least 2 among HRV + SSR and/or laser-evoked responses and/or skin biopsy and/or corneal confocal microscopy, eventually followed by monitoring of metabolic and/or immunological/ and or/paraneoplastic basis, to be repeated at 1-year follow-up. Conclusions The correct diagnostic approach to FM could promote the exclusion of the known causes of small-fiber impairment. The research toward common genetic factors would be useful to promote a more specific therapeutic approach.

show abstract

Prevalence of Fibromyalgia in Vasovagal Syncope

Cited by 12 publications

References 17 publications

Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study

Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study

Polymorphisms in B-Adrenergic Receptors Are Associated with Increased Risk to Have a Positive Head-Up Tilt Table Test in Patients with Vasovagal Syncope

Clinical criteria and diagnostic assessment of fibromyalgia: position statement of the Italian Society of Neurology-Neuropathic Pain Study Group

Contact Info

Product

Resources

About