Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

Meti, Manjunath D.; Nandibewoor, Sharanappa T.; Chimatadar, Shivamurti A.

doi:10.3906/kim-1307-4

Cited by 5 publications

(3 citation statements)

References 6 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chromium(VI) is known to be mutagenic and carcinogenic, hence, posing a serious environmental hazard [15]. It is used for many applications [16][17][18][19][20][21][22][23][24][25]. Consequently, it is of crucial importance gaining as much information as possible regarding its various forms and their interaction with organic substrates.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Oxidation of Atropine by K2Cr2O7 in Acidic Aqueous Solutions

Abdel-Halim¹,

Saleh²,

Al-Ghreizat³

2018

Asian J. Chem.

View full text Add to dashboard Cite

Oxidation of atropine (ATN) by K2Cr2O7 has been studied kinetically in aqueous strongly acidic solutions. The kinetics of this reaction was investigated at different temperatures. A constant pH and constant ionic strength were maintained constant throughout all measurements. The concentration of atropine was around an order of magnitude greater than that of K2Cr2O7, that is under pseudo first order kinetics. Rate constants were obtained by monitoring change in absorbance of K2Cr2O7 with time at its predetermined maximum wavelength. Overall rate constant and the orders of the reaction in terms of concentrations of both atropine and K2Cr2O7 were determined. Reaction runs at different temperature allows activation energy of the process to be convoluted from temperature effect on the rate of the reaction. A resonable mechanism for the reaction was proposed in accordance with kinetics results.

show abstract

Section: Introductionmentioning

confidence: 99%

Kinetics of Oxidation of Atropine by K2Cr2O7 in Acidic Aqueous Solutions

Abdel-Halim¹,

Saleh²,

Al-Ghreizat³

2018

Asian J. Chem.

View full text Add to dashboard Cite

show abstract

“…Although some reports on the oxidation of atropine by some oxidants have been published [22][23][24][25][26], there is a lack of literature on the kinetics of oxidation of this drug by permanganate ion in acid solutions. This observation prompted us to investigate the title reactions.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study

Fawzy

Zaafarany

Tirkistani

et al. 2016

View full text Add to dashboard Cite

The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H + ] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.

show abstract

“…Although some work on the oxidation of atropine by various oxidants has been performed [21][22][23][24][25], there is a lack of literature on the kinetics of oxidation of this drug by cerium(IV) in the absence or presence of a catalyst. This observation prompted us to investigate the title reaction.…”

Section: Introductionmentioning

confidence: 99%

Silver-Catalyzed Oxidation of Atropine Drug by Cerium(IV) in Aqueous Perchlorate Solutions: A Kinetics and Mechanistic Approach

Fawzy¹,

Zaafaray

Althagafi

et al. 2016

JDDMC

View full text Add to dashboard Cite

The kinetics of oxidation of atropine drug (ATR) by cerium(IV) in aqueous perchlorate solutions in the presence of silver(I) catalyst has been studied spectrophotometrically at a constant ionic strength and temperature. The reaction showed first order dependence with respect to each [Ce(IV)] and [Ag(I)], and less than unit order kinetics with respect to [ATR]. The reaction exhibited negative fractional-first order kinetics with respect to [H + ]. Increasing ionic strength and dielectric constant of the medium increased the reaction rate. In the present work, the kinetically active species of cerium(IV) was found to be Ce(OH) 3+. Addition of Ce(III) product had no significant effect on the oxidation rate. The oxidation products of atropine were identified by spectral and chemical analyses as tropine, benzaldehyde, methanol and carbon dioxide. A plausible mechanistic scheme for the catalyzed oxidation was proposed. The activation parameters of the second order rate constant were calculated and the rate law associated with the reaction mechanism was derived.

show abstract

Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

Cited by 5 publications

References 6 publications

Kinetics of Oxidation of Atropine by K2Cr2O7 in Acidic Aqueous Solutions

Kinetics of Oxidation of Atropine by K2Cr2O7 in Acidic Aqueous Solutions

Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study

Silver-Catalyzed Oxidation of Atropine Drug by Cerium(IV) in Aqueous Perchlorate Solutions: A Kinetics and Mechanistic Approach

Contact Info

Product

Resources

About