Spectroscopic and X‐ray structural characterization of new polymeric organotin(IV) carboxylates and their in vitro antifungal activities: Part II

Abstract

Funding informationCNPq, CAPES and FAPEMIG The reactions of R 3 SnCl (R = Me, Bu or Ph) with sodium 4-phenylbutyrate, Na(OPh b ), in EtOH yielded three polymeric triorganotin carboxylates, namely [R 3 Sn(OPh b )] n (R = Me (1), Bu (2) or Ph (3)). All complexes were spectroscopically characterized using Fourier transform infrared, 119 Sn Mössbauer, 1 H NMR, 13 C{ 1 H} NMR and 119 Sn{ 1 H} NMR spectral techniques. In addition, the crystal structures of 1 and 3 were determined using single-crystal X-ray diffraction. Their polymeric structures are sustained by bridging carboxylates which connect two five-coordinate Sn(IV) centres. Each metallic cation displays a distorted trigonal bipyramidal coordination geometry (Addison's parameters ranging from 0.84 in 1 to 0.77-0.91 in 3), with the oxygen atoms occupying the apical positions and the organic groups at the equatorial corners. The one-dimensional zigzag chains of 1 propagate along the b-axis, whereas 3 displays wave-like double polymeric chains along the b-axis. For both 1 and 3, parallel one-dimensional polymeric chains are interconnected by C─H⋅⋅⋅π interactions. The antifungal activity of 1-3 was screened against Candida albicans (ATCC 18804), C. tropicalis (ATCC 750), C. glabrata (ATCC 90030), C. parapsilosis (ATCC 22019), C. lusitaniae (CBS 6936) and C. dubliniensis (clinical isolate 28). The antifungal activity of 3 was noteworthy since it was not only more active than 1 and 2, but also more active than the control drugs (nystatin and fluconazole nitrate) in some cases.

Design of Promising Heptacoordinated Organotin (IV) Complexes-PEDOT: PSS-Based Composite for New-Generation Optoelectronic Devices Applications

“…For complexes 1a-1d the Δν calculated values are ranging from 286 to 326 cm −1 . A Δν (COO) > 200 cm −1 is attributable to the formation of a covalent metal oxygen bond and a monodentate coordination mode of the carboxylic group bonded to the tin atom (see Table S1) [52,53]. The coordination of both lone pair of the nitrogen atoms from pyridine and azomethine to the tin was confirmed by the existence of a vibration band at 415 cm −1 , corresponding to Sn-N.…”

Estanho: Um Metal Estratégico Ontem E Hoje

“…Vários relatos documentados na literatura registram possíveis aplicações de complexos organoestânicos como agentes antimicrobianos, antitumorais, antifúngicos, antimaláricos e anti-inflamatórios. [69][70][71][72][73][74][75][76][77][78] Em contrapartida outros artigos enfatizam alguns aspectos prejudiciais dos organoestânicos, tais como os efeitos citotóxicos, genotóxicos, mutagénicos e neurotóxico. 79 Apesar desses aspectos negativos, têm-se estudado os possíveis mecanismos de ação e os resultados de dose-resposta, bastante necessários caso se queira explorar os efeitos terapêuticos dessa classe de compostos e de seus complexos de coordenação.…”

Synthesis, Characterization, and Comparison of Disinfectant Bioactivity Test of Two Triphenyltin(IV) Compounds

“…The current results from the study on organotin(IV) compounds have revealed that some organotin(IV) carboxylates show promising activities in many biological tests. For example, they have been widely used in the biological activities as antifungal (3,(7)(8)(9), antioxidant activities (10,11), antimalarial and antiplasmodial agents (12)(13)(14)(15), antiviral agents (16,17), antitumor and anticancer (18)(19)(20), corrosion inhibitor (21)(22)(23) and antibacterial (24)(25)(26)(27)(28)(29)(30). Moreover, these compounds have been found to exhibit strong activity as disinfectant (31).…”