Spectrophotometric resolution of ternary mixtures of Dexamethasone, Polymyxin B and Trimethoprim in synthetic and pharmaceutical formulations

Comparative Study of Novel Ratio Spectra and Isoabsorptive Point Based Spectrophotometric Methods: Application on a Binary Mixture of Ascorbic Acid and Rutin

“…Salinas et al [ 27 ] proposed a spectrophotometric method depended on derivation of the ratio spectra for analyzing binary mixtures. The principal benefit of the adopted ratio-spectra derivative spectrophotometric method is the possibility of running easily measurements in correspondence of peaks so it allows using wavelength of maximum intensity (a maximum or a minimum) [ 28 – 30 ]. Furthermore, the existence of a number of maxima and minima is another benefit as it permits the quantitation of active drugs in presence of other drugs and additives which probably intervene with the assay.…”

Simultaneous determination of the brand new two-drug combination for the treatment of hepatitis C: Sofosbuvir/ledipasvir using smart spectrophotometric methods manipulating ratio spectra

“…It is required first to optimize the following factors: concentration of the divisor, Δ λ to compute the first derivative, smoothing and wavelengths at zero-crossing. [19][20][21][22] SFB was estimated in presence of LDP by DR 1 using the normalized spectrum of LDP as divisor as shown in Figure 5. The derivative of the constant LDP LDP′ is zero.…”

Recent Advances in the Analysis of Steroid Hormones and Related Drugs

“…19 The accuracy and precision of the determination of even as low a quantity as 2 mg/vial dexamethasone in the presence of 250 and 10 mg of vitamins B6 and B12, respectively, in an injection formulation were good. 20 Other 3-component formulations containing low quantities of dexamethasone resolved by partial least-squares regression analysis and other chemometric methods were Polymyxin B, trimethoprim, dexamethasone 21 and chlorpheniramine, naphazoline and dexamethasone. 22 In the latter case, the use of artificial neural network analysis was necessary for the determination of dexamethasone due to the non-linearity caused by interactions among the components.…”