Spectrophotometric Method for Simultaneous Estimation of Formoterol Fumarate and Mometasone Furoate in Respicaps

R, Bhangale P; Jain, Hemant Kumar

doi:10.7897/2230-8407.04650

Cited by 7 publications

(4 citation statements)

References 6 publications

(6 reference statements)

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“…This instrumentation setup ensures precise and accurate measurement of absorbance within the specified wavelength range, facilitating the reliable determination of the concentrations of Formoterol fumarate and Anhydrous Beclomethasone Dipropionate in pressurized metered dose inhalers. [15][16]…”

Section: Materials and Methods [15-18] 21 Instrument Usedmentioning

confidence: 99%

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Development and Validation of a Viable and User-Friendly Spectrophotometric Analytical Method for Estimation of Assay of Formoterol and Beclomethasone in Metered Dose Inhaler Formulation

Musale,

Shah

2024

ijcsrr

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The primary aim of this research endeavor is to innovate a viable and user-friendly UV spectroscopic approach for quantifying formoterol and beclomethasone within metered dose inhalers (MDIs). These formulations, amalgamating Beclomethasone Dipropionate (BDP) and Formoterol Fumarate (FF), are extensively employed in managing bronchial asthma and chronic obstructive pulmonary diseases. Although analytical techniques already exist for assessing formoterol and beclomethasone in combination dry powder inhalers, this study concentrates on devising and validating a UV spectrophotometric method for simultaneously quantifying formoterol fumarate and Anhydrous Beclomethasone Dipropionate in Pressurized Metered Dose Inhalers (pMDIs). The estimation is performed at a wavelength of 240 nm for Beclomethasone Dipropionate and 216 nm for Formoterol Fumarate. Both drugs demonstrate satisfactory linearity within the concentration range of 10-30 μg/ml for BDP and 0.3 to 0.9 μg/ml for FF at wavelengths of 240 nm (r^2=0.999) and 216 nm (r^2=0.999), respectively. The Beer-Lambert law is adhered to within the concentration range of 10-30 μg/ml for BDP and 0.3-0.9 μg/ml for FF. The proposed methods are subjected to validation following ICH guidelines to assess accuracy, method precision, specificity, among other parameters. As a result, the proposed method can be effectively employed for the simultaneous determination of Beclomethasone Dipropionate and Formoterol Fumarate in routine analytical applications, offering a rapid and reliable solution for pharmaceutical analysis in the field.

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Section: Materials and Methods [15-18] 21 Instrument Usedmentioning

confidence: 99%

“…The innovative combination metered dose inhaler formulation of Formoterol and Beclomethasone was developed utilizing these high-quality materials, paving the way for enhanced therapeutic outcomes in respiratory care. [15][16]…”

Section: Reagents and Chemicalsmentioning

confidence: 99%

Development and Validation of a Viable and User-Friendly Spectrophotometric Analytical Method for Estimation of Assay of Formoterol and Beclomethasone in Metered Dose Inhaler Formulation

Musale,

Shah

2024

ijcsrr

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“…The objective of validation of an analytical procedure is to demonstrate whether the procedure is suitable for its intended purpose. The proposed method was validated for various parameters such as Linearity, Accuracy, Precision, Limit of detection (LOD) and Limit of Quantitation (LOQ) according to ICH Q2 (R1) guideline 9 .…”

Section: Methods Validationmentioning

confidence: 99%

Development and Validation for Uv Spectrometric Estimation of Ambroxol Hydrochloride in Bulk and Tablet Dosage Form Using Area Under Curve Method

Rangnath¹,

Kumar²,

Namdeorao³

2014

Int. Res. J. Pharm.

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This paper describes development and validation of UV spectrophotometric method for the estimation of Ambroxol hydrochloride in bulk and pharmaceutical formulation using area under curve method. The standard and sample solutions of Ambroxol hydrochloride were prepared in methanol. The area under curve in between 238 to 258 nm was measured. The method followed linearity in the range of 2-12 μg/ml with correlation coefficient value of 0.999. This method was validated for various parameters according to ICH guideline Q2 (R1). Satisfactory values of Percent relative standard deviation for the intra-day and interday precision indicated that method was precise. The mean percentage recovery studies were found to be 100.69 %. Limit of Detection and Limit of Quantitation were calculated as 0.0841 μg/ml and 0.2551 μg/ml, respectively. Validation results suggest that the further developed method can be used for routine quality control analysis studies for Ambroxol hydrochloride in bulk and tablet dosage form.

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“…1b. Literature survey revealed that various analytical methods such as spectrophotometry [5][6][7][8][9], HPLC [10][11][12][13][14][15][16][17][18], HPTLC [19] and NMR [20] have been reported for determination of Formoterol fumarate dihydrate (FFD) and Fluticasone propionate (FP) in bulk drug formulations or combination with other drugs. Hence the objective of the present work is to develop a simple, precise, accurate, validated simultaneous equation spectrophotometric method for simultaneous estimation of formoterol fumarate dihydrate and fluticasone propionate in pure drug and pharmaceutical formulations.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Equation Spectrophotometric Methods for Simultaneous Estimation of Formoterol Fumarate Dihydrate and Fluticasone Propionate in Pure Drug and Pharmaceutical formulations.

Gowekar¹,

Wadher²

2017

JCPR

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A simple, accurate, sensitive and economical spectrophotometric method have been developed and subsequently validated for determination of Formoterol Fumarate Dihydrate (FFD) and Fluticasone Propionate (FP) in bulk and pharmaceutical formulation. For the simultaneous equation method, the estimation of FFD and FP was carried out at 215nm (λmax of FFD) and 236 nm (λmax of FP), respectively. Calibration curves of FFD and FP were found to be linear in the concentration ranges of 6-36 μg/mL and 20-120 μg/mL for FFD and FP, respectively.

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Spectrophotometric Method for Simultaneous Estimation of Formoterol Fumarate and Mometasone Furoate in Respicaps

Cited by 7 publications

References 6 publications

Development and Validation of a Viable and User-Friendly Spectrophotometric Analytical Method for Estimation of Assay of Formoterol and Beclomethasone in Metered Dose Inhaler Formulation

Development and Validation of a Viable and User-Friendly Spectrophotometric Analytical Method for Estimation of Assay of Formoterol and Beclomethasone in Metered Dose Inhaler Formulation

Development and Validation for Uv Spectrometric Estimation of Ambroxol Hydrochloride in Bulk and Tablet Dosage Form Using Area Under Curve Method

Simultaneous Equation Spectrophotometric Methods for Simultaneous Estimation of Formoterol Fumarate Dihydrate and Fluticasone Propionate in Pure Drug and Pharmaceutical formulations.

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