Simultaneous Equation Spectrophotometric Methods for Simultaneous Estimation of Formoterol Fumarate Dihydrate and Fluticasone Propionate in Pure Drug and Pharmaceutical formulations.

Abstract

A simple, accurate, sensitive and economical spectrophotometric method have been developed and subsequently validated for determination of Formoterol Fumarate Dihydrate (FFD) and Fluticasone Propionate (FP) in bulk and pharmaceutical formulation. For the simultaneous equation method, the estimation of FFD and FP was carried out at 215nm (λmax of FFD) and 236 nm (λmax of FP), respectively. Calibration curves of FFD and FP were found to be linear in the concentration ranges of 6-36 μg/mL and 20-120 μg/mL for FFD and FP, respectively.