Spectrophotometric determination of some anti-inflammatory agents using N-bromosuccinimide

Phosphorimetric Determination of Indomethacin in Pharmaceutical Formulations

“…26 The estimated values were at least one order of magnitude lower than those previously reported for fluorimetric and spectrophotometric methods. [3][4][5][6][7][8][9]…”

“…1), is a non-steroidal anti-inflammatory agent commonly employed in the treatment of rheumatoid arthritis. 1 Methods for the determination of indomethacin in dosage forms are mainly based on analytical techniques such as titration, 2 polarography, 3 spectrophotometry [4][5][6][7] and fluorimetry. 8,9 Although the analytical figures of merit obtained with these methods are satisfactory, [3][4][5][6][7][8][9] their experimental procedures include tedious extraction steps and time-consuming reactions inconvenient for routine analysis.…”

Indirect Sequential Injection Enzymatic Determination of Allopurinol in Pharmaceuticals Based on Xanthine Oxidase Inhibition

“…[1] Furthermore, the increasing interest in pharmaceutical compounds that may interfere on the in vivo oxidant status has led to studies for putative effects of allopurinol upon organ reperfusion injuries or upon disorders where endogenous antioxidant mechanisms are compromised, such as coronary heart disease, [2,3] diabetes, [4] and cirrhosis. [5] In this context, a variety of methods based on titrimetry, [6] spectrophotometry, [7][8][9] fluorimetry, [10] electrochemistry, [11][12][13][14] electrochemiluminescence, [15] and phosphorescence [16] are available for determination of allopurinol in pharmaceutical formulations. Methods for multi-analyte determination (including allopurinol) based on capillary electrophoresis [17] or HPLC with UV detection [18] have also been described.…”

Development of a potentiometric mefenamate ion sensor for the determination of mefenamic acid in pharmaceuticals and human blood serum

“…flow injection analysis [15], potentiometric titration [16], polarography [17,18] and voltammetry [19]. However, many of these methods are time-consuming [4][5][6][7]9,11,12,[17][18][19] and/or require expensive equipment [6][7][8][9][10][12][13][14]. Thus, there is an important demand for simple, low-cost, sensitive and rapid alternative methods for the determination of MFA in pharmaceuticals and biological fluids.…”

“…These methods include spectrophotometry [3][4][5], chromatography [6][7][8][9], capillary electrophoresis [10,11], atomic absorption spectrometry [12], nuclear magnetic resonance spectroscopy [13], derivative synchronous fluorescence spectrometry [14], * Corresponding author. Fax: +55 16 33227932.…”