Development of a potentiometric mefenamate ion sensor for the determination of mefenamic acid in pharmaceuticals and human blood serum

Santini, Alberto; Pezza, Helena Redigolo; Pezza, Leonardo

doi:10.1016/j.snb.2007.05.039

Cited by 43 publications

(22 citation statements)

References 37 publications

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“…Potentiometry involving ISE with poly(vinyl chloride) membrane for aluminium(III) (Piccin et al 2004) and furosemide (Dias et al 2004), electrode of a second kind, namely PtjHgjHg 2 (analyte) x jgraphite for diclofenac (Santini et al 2006a), ibuprofenate (Santini et al 2006b), mefenamic acid (Santini et al 2007), and naproxen (Santini et al 2006a), and a flexible minisensor based on manganese dioxide-composite for hydrogen peroxide (Fagury et al 2005) have been developed.…”

Section: Electroanalytical Chemistrymentioning

confidence: 99%

A Glimpse of Recent Developments in Brazilian Analytical Chemistry

et al. 2008

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This review highlights some relevant contributions proposed by Brazilian analytical research groups mainly after 2004. This year was chosen due to an earlier publication of an overview with similar scope by Andrade et al. (2004). The selected papers are representative, but the authors have not tried to present a comprehensive overview of the aforementioned period. The chosen areas for discussion were automation in analytical chemistry, chemometrics, chromatography, capillary electrophoresis and mass spectrometry, electroanalytical chemistry, environmental analytical chemistry, preconcentration and separation procedures, and spectrochemical analysis. A glimpse of the Brazilian contributions shows the stage of development of analytical chemistry in Brazil, with emphasis on major advancements and critical needs.

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Section: Electroanalytical Chemistrymentioning

confidence: 99%

A Glimpse of Recent Developments in Brazilian Analytical Chemistry

et al. 2008

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“…Thus, detection of the drug has been investigated using various techniques, such as high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), spectroph-otometric methods, and capillary electrochromatography. [27][28][29][30][31][32][33][34][35][36] A new analytical technique is required with a better limit of detection (LOD), good performance and high speed.…”

Section: Introductionmentioning

confidence: 99%

Soft Ionization of Metallo-Mefenamic Using Electrospray Ionization Mass Spectrometry

Abdelhamid¹,

Wu²

2015

Mass Spectrometry Letters

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Detection of mefenamic acid (M, non-steroidal anti-inflammatory drug, NSAIDs) and its metallodrug was investigated using electrospray ionization mass spectrometry (ESI-MS) and fluorescence spectroscopy. ESI-MS data (500 µL, 1×10-3 M) revealed high detection sensitivity for the drug and metallodrug. ESI-MS spectra revealed peaks at 242, 580, and 777 Da corresponding to [M+H]+, [63Cu(M-H)2(H2O)2+H]+, and [56Fe(M-H)3+H]+, respectively. The metal:mefenamic ratios of ESI-MS spectra are in complete agreement with the fluorescence spectroscopy results (1:2 for Cu(II) and 1:3 for Fe(III)). ESI is a soft ionization technique that can be used on labile metallo-mefenamic acids and is promising for the detection of these species in environmental samples and biological fluids.

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“…sarin, soman and tabun and represent also an environmental problem [10][11][12]. Daily income into human body is filled mostly with drinking water and fluoridated salt [13,14]. According to WHO the maximum limit of fluoride in drinking water is 1.5 mg L À1 [15].…”

Section: Introductionmentioning

confidence: 99%