Spectral fiber sensors for cancer diagnostics in vitro

Artyushenko, Viacheslav; Schulte, Franziska; Zabaryło, Urszula; Berlien, H.-P.; Usenov, Iskander; Gilani, T. Saeb; Eichler, Hans Joachim; Pieszczek, Ł.; Bogomolov, Andrey; Krause, Hans; Minet, Olaf

doi:10.1364/ecbo.2015.953720

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…In addition, results of SERS showed good agreement with those obtained from UV-Vis (absorption mode) which points out the important role of electromagnetic model for enhancement of Raman scattering. However, (5) E phonon = E photon(laser) − E scattered(photon) (6) ∇̄p honon =̄p hoton(laser) −̄s cattered(photon) due to surface oxidation of Mn which may act as a buffer between 4,4′-bipyridine molecules and the Mn atoms, one may also consider the role of charge transfer mechanism in this work. Therefore, one cannot define exactly which of these two mechanisms are more likely to explain the results of this work as also being commented in most of the published literature.…”

Section: Discussionmentioning

confidence: 99%

“…This work became the base for the effect of metallic substrates on the enhancement of Raman peaks. Since then different types of Raman enhancement spectroscopy such as surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS) are reported which have many applications in pharmacy [3][4][5], medicine [6][7][8][9][10][11][12][13], geology [14][15][16], forensic investigations [17][18][19][20] and many other fields. Theoretical and experimental studies have shown that the reason for intensification of Raman peaks by metallic substrates is formation and resonance of localized surface plasmons on the rough surface of metals [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Detection of overtone and combined peaks using Mn/Cu helical star-shaped (pine-tree-like) sculptured thin films in surface-enhanced Raman spectroscopy

2019

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Mn helical star-shaped (pine-tree-like) nano-sculptured thin films with three-, four-and fivefold symmetry on copper substrates were produced using oblique angle deposition method in conjunction with rotation of sample holder at certain angles. Raman spectroscopy of the samples which were subjected to impregnation by 4,4′-bipyridine (C 10 H 8 N 2) solution was carried out by 632.8 nm wavelength laser. The analysis of the Raman spectra showed enhancement for the 4,4′-bipyridine main bands (1592 and 1297 cm −1) belonging to the C=C stretching mode, aromatic ring stretching ring and in-plane ring mode of 4,4′-bipyridine, same as results obtained for Ag nano-structures. In addition, overtone and combined peaks are detected that may be related to the particular sculptured structure of the thin films fabricated in this work and the laser wavelength used for Raman spectroscopy. UV-Vis (absorption mode) spectra showed consistent observations with the SERS results leading to important role of surface electromagnetic selection rule in intensification of SERS, in addition pointing out the importance of the effect of the size of hot spots on the frequency of the localized surface plasmonic oscillations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of overtone and combined peaks using Mn/Cu helical star-shaped (pine-tree-like) sculptured thin films in surface-enhanced Raman spectroscopy

2019

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“…A typical view of the patient biopsies is presented in Figure 1 . Some further details on sample preparation can be found in previous publications by the authors [ 23 , 24 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

“…MIR spectra were obtained at the resolution of 8 cm −1 at 64 scans. Typical spectrum acquisition time at these settings was about 46 s. Some further details on MIR spectroscopic investigation of kidney samples have been published before [ 27 ]. Experimental setups are presented in Figure 2 .…”

Section: Methodsmentioning

confidence: 99%

Synergy Effect of Combining Fluorescence and Mid Infrared Fiber Spectroscopy for Kidney Tumor Diagnostics

Bogomolov

Belikova

Zabaryło

et al. 2017

Sensors

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Matching pairs of tumor and non-tumor kidney tissue samples of four patients were investigated ex vivo using a combination of two methods, attenuated total reflection mid infrared spectroscopy and fluorescence spectroscopy, through respectively prepared and adjusted fiber probes. In order to increase the data information content, the measurements on tissue samples in both methods were performed in the same 31 preselected positions. Multivariate data analysis revealed a synergic effect of combining the two methods for the diagnostics of kidney tumor compared to individual techniques.

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“…Malignant tumors are currently diagnosed using a number of methods, including non-invasive techniques such as computer tomography, ultrasound and X-ray scanning, as well as invasive procedures, including biopsies and diagnostic surgeries. Optical spectroscopy of the biological tissue, also called spectral histopathology [ 2 ], is a relatively new and highly promising approach to the non-invasive tumor diagnostics that has been actively investigated since the 1990s. Spectroscopic measurements are typically inexpensive and rapid, which makes the approach very well suited for diagnostic screening and routine prophylactic check-ups.…”

Section: Introductionmentioning

confidence: 99%

Development and Testing of an LED-Based Near-Infrared Sensor for Human Kidney Tumor Diagnostics

Bogomolov

Zabaryło

Kirsanov

et al. 2017

Sensors

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Optical spectroscopy is increasingly used for cancer diagnostics. Tumor detection feasibility in human kidney samples using mid- and near-infrared (NIR) spectroscopy, fluorescence spectroscopy, and Raman spectroscopy has been reported (Artyushenko et al., Spectral fiber sensors for cancer diagnostics in vitro. In Proceedings of the European Conference on Biomedical Optics, Munich, Germany, 21–25 June 2015). In the present work, a simplification of the NIR spectroscopic analysis for cancer diagnostics was studied. The conventional high-resolution NIR spectroscopic method of kidney tumor diagnostics was replaced by a compact optical sensing device constructively represented by a set of four light-emitting diodes (LEDs) at selected wavelengths and one detecting photodiode. Two sensor prototypes were tested using 14 in vitro clinical samples of 7 different patients. Statistical data evaluation using principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) confirmed the general applicability of the LED-based sensing approach to kidney tumor detection. An additional validation of the results was performed by means of sample permutation.

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Spectral fiber sensors for cancer diagnostics in vitro

Cited by 7 publications

References 12 publications

Detection of overtone and combined peaks using Mn/Cu helical star-shaped (pine-tree-like) sculptured thin films in surface-enhanced Raman spectroscopy

Detection of overtone and combined peaks using Mn/Cu helical star-shaped (pine-tree-like) sculptured thin films in surface-enhanced Raman spectroscopy

Synergy Effect of Combining Fluorescence and Mid Infrared Fiber Spectroscopy for Kidney Tumor Diagnostics

Development and Testing of an LED-Based Near-Infrared Sensor for Human Kidney Tumor Diagnostics

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