Spectral-Domain Optical Coherence Tomography Angiography for the Diagnosis and Evaluation of Polypoidal Choroidal Vasculopathy

Abstract

Purpose: To compare the diagnostic ability of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV). Methods: Retrospective review of 47 eyes with PCV imaged with ICGA and OCTA. For each eye, it was determined which imaging modality better delineated the PCV complex. The presence of a branching vascular network (BVN) and polyp(s) were noted. Results: PCV was better visualized with ICGA in 21 eyes (44.7%) and with OCTA in 9 eyes (19.2%). The results were comparable in 17 eyes (36.2%). Of the 44 eyes with BVN on ICGA, 41 eyes (93.2%) also showed BVN on OCTA. Of the 28 eyes with polyp(s) on ICGA, 22 eyes (78.6%) also showed polyp(s) on OCTA. Polyps were high-flow lesions or faint low-flow dilations on OCTA. Conclusion: OCTA readily detects BVNs and can detect most polyps, but in many cases ICGA is better able to detect the PCV complex.

Treatment for a Subtype of Exudative Macular Degeneration—Another Mountain Climbed

“…Because of the potential difficulty of accessing ICGA and of diagnosing PCV with ICGA, other more commonly obtained noninvasive diagnostic tests have been evaluated to make the diagnosis of PCV, including fundus photography, optical coherence tomography (OCT), 6 en face OCT, 7 and OCT angiography. 8 Chaikitmongkol and colleagues 6 showed that highly suggestive signs of PCV Related article page 935 on fundus photographs and OCT can make the diagnosis of PCV with high sensitivity and specificity without ICGA. En face OCT is a widely available method of evaluating a potential PCV lesion, which is visualized as a dilated, irregular vascular structure with hyperechogenic borders and polypoidal vascular dilations similar to what is seen on ICGA.…”

Detection Rate and Diagnostic Value of Optical Coherence Tomography Angiography in the Diagnosis of Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis

“…After excluding 643 records by screening the titles and abstracts, a total of 63 manuscripts were fully examined (see Figure 1). We ultimately included 20 studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] (640 eyes, 563 PCV eyes) for meta-analysis (see Table 1). We included 20 studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] reporting the polyp detection rate, 15 studies [10-12, 14, 15, 17-23, 25, 28, 29] reporting the BVN detection rate, and 4 articles [10,11,17,21] (6 studies) reporting the sensitivity and specificity of OCTA and ICGA for diagnosing PCV from wAMD eyes.…”

Spectral-Domain Optische Kohärenztomographie- Angiographie in der Diagnostik und Beurteilung von polypoidaler choroidaler Vaskulopathie

“…Die polypoidale choroidale Vaskulopathie (PCV) beschreibt eine Sonderform der Typ 1 CNV, bei der es zu aneurysmatischen Gefäßaussackungen mit oder ohne Ausbildung eines abnormalen vaskulären Verzweigungsnetzes (BVN, branching vascular network) kommt [1,2]. Bis heute gilt die ICGA als Goldstandard in der Diagnostik [1].…”

“…Bis heute gilt die ICGA als Goldstandard in der Diagnostik [1]. Mit der sehr interessanten Frage der Rolle der OCTA in der Diagnostik und Evaluation der PCV beschäftigen sich de Carlo et al in einem kürzlich erschienenen Artikel [2]. …”