Detection Rate and Diagnostic Value of Optical Coherence Tomography Angiography in the Diagnosis of Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis

Wang, Yuelin; Yang, Jingyuan; Li, Bing; Yuan, Mingzhen; Chen, Youxin

doi:10.1155/2019/6837601

Cited by 20 publications

(8 citation statements)

References 27 publications

(39 reference statements)

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“…A meta-analysis of OCTA in PCV included 573 eyes from 20 studies and evaluated the pooled sensitivity and specificity of OCTA in detecting polypoidal lesions and BNN 62. The detection rate of BNN (0.86) was higher than that of polypoidal lesions (0.67).…”

Section: Updates On Diagnosis Of Pcvmentioning

confidence: 99%

Polypoidal Choroidal Vasculopathy: Updates on Risk Factors, Diagnosis, and Treatments

Ruamviboonsuk

Cheung

Chainakul

et al. 2023

Asia-Pacific Journal of Ophthalmology

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There have been recent advances in basic research and clinical studies in polypoidal choroidal vasculopathy (PCV). A recent, large-scale, population-based study found systemic factors, such as male gender and smoking, were associated with PCV, and a recent systematic review reported plasma C-reactive protein, a systemic biomarker, was associated with PCV. Growing evidence points to an association between pachydrusen, recently proposed extracellular deposits associated with the thick choroid, and the risk of development of PCV. Many recent studies on diagnosis of PCV have focused on applying criteria from noninvasive multimodal retinal imaging without requirement of indocyanine green angiography. There have been attempts to develop deep learning models, a recent subset of artificial intelligence, for detecting PCV from different types of retinal imaging modality. Some of these deep learning models were found to have high performance when they were trained and tested on color retinal images with corresponding images from optical coherence tomography. The treatment of PCV is either a combination therapy using verteporfin photodynamic therapy and anti-vascular endothelial growth factor (VEGF), or anti-VEGF monotherapy, often used with a treat-and-extend regimen. New anti-VEGF agents may provide more durable treatment with similar efficacy, compared with existing anti-VEGF agents. It is not known if they can induce greater closure of polypoidal lesions, in which case, combination therapy may still be a mainstay. Recent evidence supports long-term follow-up of patients with PCV after treatment for early detection of recurrence, particularly in patients with incomplete closure of polypoidal lesions.

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Section: Updates On Diagnosis Of Pcvmentioning

confidence: 99%

Polypoidal Choroidal Vasculopathy: Updates on Risk Factors, Diagnosis, and Treatments

Ruamviboonsuk

Cheung

Chainakul

et al. 2023

Asia-Pacific Journal of Ophthalmology

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“…“En face” OCTA may be useful for understanding the pathogenesis of PCV and managing it [ 50 ]. A systematic review and meta-analysis by Wang et al reported a promising role of OCTA in PCV diagnosis, as demonstrated by an AUC of 0.87 (0.84–0.90) [ 55 ]. The branched vascular network (BVN) can also be identified easily due to its high flow characteristics.…”

Section: Diagnosismentioning

confidence: 99%

“…The branched vascular network (BVN) can also be identified easily due to its high flow characteristics. However, the polypoidal lesion detection rate can be highly variable, between 17% and 92% [ 45 ], due to slow and turbulent flow within the lesion, the polyps being too small or covered by BVN blood flow signals, or the curvature of the vessels, making it challenging to capture red blood cell motion [ 45 , 55 ]. Other OCTA disadvantages include segmentation errors of peaked PED in PCV that require experienced use of slabs.…”

Section: Diagnosismentioning

confidence: 99%

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Current Trends in Clinical Characteristics, Diagnosis, and Treatment of Polypoidal Choroidal Vasculopathy: A Perspective from Vietnam

Dat¹,

Hien

Quan³

et al. 2022

JCM

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Polypoidal choroidal vasculopathy (PCV) is a common choroidal disease in the Asian population including Vietnam and is characterized by subretinal red-orange nodules, pigmented epithelium detachment, and massive subretinal hemorrhage. The recent focus on PCV in Vietnam can be attributed to advancements in PCV diagnosis and treatment. However, there is a scarcity of published literature and clinical data on PCV in the Vietnamese population, highlighting a key knowledge gap in this region. In order to address this gap, we gathered the opinions of experienced clinicians and retinal experts in Vietnam and reviewed available medical literature with the aim of: (i) providing an overview of PCV in the Vietnamese population—in terms of epidemiology, clinical characteristics, and management; (ii) tailoring international/national guidelines for the diagnosis and management of PCV, in line with available resources and medical equipment in Vietnam; and (iii) identifying gaps in clinical data in order to guide future PCV research in Vietnam and other countries with similar clinical conditions. The present review will enable healthcare providers and researchers to gain insight into current clinical practices and the limitations of PCV management in Vietnam and provide optimal and effective solutions.

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“…Thus, combined sensitivity and specificity of OCTA for the diagnosis of AT1 is 77% and 84%, respectively. [12][13][14][15] There are few reports studying OCTA for the diagnosis of AT1 in Caucasian patients.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography analysis of aneurismal type 1 neovascularization in a cohort of white patients

Hernández

Sargues

Adsuara

et al. 2021

European Journal of Ophthalmology

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Introduction: To evaluate the detection rate of aneurysmal type 1 neovascularization (AT1) in Caucasian patients using optical coherence tomography angiography (OCTA) and to describe OCTA characteristics of AT1 in a cohort of white patients. Methods: We conducted an observational retrospective study in 44 eyes of 43 patients with AT1. All patients underwent a complete ophthalmologic examination, including fundus imaging, indocyanine green angiography, optical coherence tomography, and OCTA. Branching vascular network (BVN) and polyp detection rates by OCTA were evaluated. Furthermore, we described BVN and polyp morphologies on en face OCTA and flow of polyps on B-scan OCTA. Results: En face OCTA revealed BVN in 84.09% of cases and polypoidal lesions in 86.36% of cases. B-scan OCTA showed BVN and polyps in 95.45% and 93.18% of the patients, respectively. “Trunk” BVNs (51.35%) and “ring” polyps (47.37%) were the most frequent morphologies observed in our cohort, and “patchy hyperflow” (80.49%) signal was the most common visualized in our patients. Regarding OCT parameters, CT under polyps was higher in patients with positive detection of polyps on B-scan OCTA. Conclusion: OCTA is a possible diagnosis tool in Caucasian patients with AT1. To the best of our knowledge, this is the largest study performed in Caucasian patients regarding OCTA diagnostic abilities and features.

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Detection Rate and Diagnostic Value of Optical Coherence Tomography Angiography in the Diagnosis of Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis

Cited by 20 publications

References 27 publications

Polypoidal Choroidal Vasculopathy: Updates on Risk Factors, Diagnosis, and Treatments

Polypoidal Choroidal Vasculopathy: Updates on Risk Factors, Diagnosis, and Treatments

Current Trends in Clinical Characteristics, Diagnosis, and Treatment of Polypoidal Choroidal Vasculopathy: A Perspective from Vietnam

Optical coherence tomography angiography analysis of aneurismal type 1 neovascularization in a cohort of white patients

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