Specific Oxygenated Groups Enriched Graphene Quantum Dots as Highly Efficient Enzyme Mimics

Wang, Huan; Liu, Chaoqun; Liu, Zhen; Ren, Jinsong; Qu, Xiaogang

doi:10.1002/smll.201703710

Cited by 100 publications

(59 citation statements)

References 67 publications

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“…Meanwhile, the K m value with H 2 O 2 as substrate was 0.310 mM, suggesting that only tiny amount of H 2 O 2 is required to achieve maximum catalytic activity . The reduced K m value might be related to the presence of abundant carboxyl and carbonyl groups on the surface of γ‐Fe 2 O 3 /CeO 2 ‐PDI, which acted as binding sites and active sites of substrates during the catalytic process, respectively …”

Section: Resultssupporting

confidence: 60%

Perylene diimide‐modified magnetic γ‐Fe₂O₃/CeO₂ nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C

Lian

Liu

Li³

et al. 2019

Applied Organom Chemis

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Perylene diimide‐modified magnetic γ‐Fe2O3/CeO2 nanoparticles (γ‐Fe2O3/CeO2‐PDI) were prepared and exhibited excellent peroxidase‐like activity. The samples were characterized by HR‐TEM, XRD, Raman, N2 adsorption, magnetic strength and XPS. The obtained γ‐Fe2O3/CeO2‐PDI had size of 10~20 nm with high specific surface area of 77 m2/g, and could be easily separated from the aqueous solution by using a magnet, which are in favor of its practical application. Due to the decoration of PDI, the γ‐Fe2O3/CeO2‐PDI possessed more surface defects (Ce3+) and active oxygen species than that of γ‐Fe2O3/CeO2, resulting in the outstanding catalytic performance. And the composite catalyst also showed highly sensitive and selectivity toward VC with a limit of detection of 0.45 μM. Based on the fluorescent results, a possible hydroxyl radical (•OH) catalytic mechanism was proposed. It is believed that the as‐prepared γ‐Fe2O3/CeO2‐PDI nanoparticles are promising biosensors applied for biomedical and food analysis.

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Section: Resultssupporting

confidence: 60%

Perylene diimide‐modified magnetic γ‐Fe₂O₃/CeO₂ nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C

Lian

Liu

Li³

et al. 2019

Applied Organom Chemis

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“…On the other hand, they may cause the mediated signaling cascade. Moreover, nanoparticles may potentially act like enzyme in many biological chemical reactions, named as nanozyme, though whether C‐dots also have the nanozyme‐inhibitor activity is unclear. Herein, we tested the function of C‐dots in peroxidase activity with pH‐mediated regulation and their potential to react with reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

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Carbon nanodots (C‐dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C‐dots can enhance targeted cancer therapy. However, in‐depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit‐derived C‐dots, exhibits significant DNA damage; Annexin V/7‐AAD‐mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C‐dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit‐derived C‐dots are observed inhibiting the horseradish peroxidase. Moreover, the C‐dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim‐1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C‐dots, derived from the date‐pit, as an efficient, low‐cost, and green nanomaterial are reveled for cancer therapy and anti‐infection.

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“…However, it is noteworthy that Prussian blue itself has peroxidase activity. Qu's group studied the effect of surface functional groups on peroxidase activity in graphene quantum dots (GQD) ( Figure 3) [14]. Carbonyl, hydroxyl, and carboxyl groups on the surface of GQD were selectively modified by benzoic anhydride (BA), phenylhydrazine (PH), and 2-bromo-1-phenylethyl ketone (BrPE), respectively.…”

Section: Surface Modificationmentioning

confidence: 99%

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

et al. 2019

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Natural enzymes, such as biocatalysts, are widely used in biosensors, medicine and health, the environmental field, and other fields. However, it is easy for natural enzymes to lose catalytic activity due to their intrinsic shortcomings including a high purification cost, insufficient stability, and difficulties of recycling, which limit their practical applications. The unexpected discovery of the Fe3O4 nanozyme in 2007 has given rise to tremendous efforts for developing natural enzyme substitutes. Nanozymes, which are nanomaterials with enzyme-mimetic catalytic activity, can serve as ideal candidates for artificial mimic enzymes. Nanozymes possess superiorities due to their low cost, high stability, and easy preparation. Although great progress has been made in the development of nanozymes, the catalytic efficiency of existing nanozymes is relatively low compared with natural enzymes. It is still a challenging task to develop nanozymes with a precise regulation of catalytic activity. This review summarizes the classification and various strategies for modulating the activity as well as research progress in the different application fields of nanozymes. Typical examples of the recent research process of nanozymes will be presented and critically discussed.

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Specific Oxygenated Groups Enriched Graphene Quantum Dots as Highly Efficient Enzyme Mimics

Cited by 100 publications

References 67 publications

Perylene diimide‐modified magnetic γ‐Fe₂O₃/CeO₂ nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C

Perylene diimide‐modified magnetic γ‐Fe₂O₃/CeO₂ nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

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Specific Oxygenated Groups Enriched Graphene Quantum Dots as Highly Efficient Enzyme Mimics

Cited by 100 publications

References 67 publications

Perylene diimide‐modified magnetic γ‐Fe2O3/CeO2 nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C

Perylene diimide‐modified magnetic γ‐Fe2O3/CeO2 nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

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Product

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Perylene diimide‐modified magnetic γ‐Fe₂O₃/CeO₂ nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C

Perylene diimide‐modified magnetic γ‐Fe₂O₃/CeO₂ nanoparticles as peroxidase mimics for highly sensitive colorimetric detection of Vitamin C