Specific Lamellar Structures of Agranular Endoplasmic Reticulum in the Senile Mouse Adrenal Cortex

Characteristic reaction of the mouse adrenal cortical cell to osmium impregnation.

“…Highly organized lamellar structures have been encountered in the mouse adrenal cortical cells, especially in the reticular zone cells (SATO, 1967;SHELTON and JONES, 1971;MOORE and CALLAS, 1975;FUJITA, 1977;SETOGUCHI et al, 1979). As SETOGUCHI The authors agree with their opinion that this structure might represent a part of the smooth endoplasmic reticulum.…”

“…According to SETOGUCHI et al (1979), the lamellar bodies are originated from the endoplasmic reticulum, because their ends are continuous with the cisternae of smooth endoplasmic reticulum as well as of rough endoplasmic reticulum.…”

Unusual Configurations of Endoplasmic Reticulum in Pinealocytes of the Djungarian Hamster (Phodopus sungorus)

“…Morphologically identical structures were found in the pineal gland of a few other species (mole: Pevet [1974]; mole-rat: Pevet et al [ 19761;noctule bat: Pevet et al [ 19771;troglophilic fish: McNulty [ 19781;13-lined ground squirrels: McNulty and Dombrowski [ 19801;Chinese hamster: McNeill and Smith [ 19821;Matsushima and Morisawa [ 19821; white-foot mouse: King et al [ 19821). Apart from their occurrence in the pineal gland, they have been observed mainly in steroid-producing cells (adrenal cortex of mice: Sat0 [ 19671; Shelton and Jones [ 19711;Moore and Callas [ 19751;Setoguti et al [1979]; Leydig cells of mice: Baillie [1964]; Ohata [1979]). A comparison of these membranous stacks as presented in the current study with those observed in the pineal gland of other species and in steroid-producing organs reveals a striking similarity.…”

Age-related Changes in the Adrenal Cortex: Insights and Implications

“…Cellular senescence is a stable state of cell cycle arrest, and can be induced by a variety of stressors including severe DNA damage, telomere attrition, or oncogene activation [ 99 , 100 ]. Classically, senescent cells are characterized by several distinct features, including changes in cell morphology, accumulation of lysosomal senescence-associated β-galactosidase, and upregulation of the cyclin-dependent kinase inhibitors (CDKi) p16 and p21, some of which have been noted in the adrenal [ 36 , 54 , 101 ]. Moreover, unique from other forms of cell cycle arrest, senescent cells activate a hypersecretory state known as the senescence-associated secretory phenotype (SASP) [ 99 , 100 ].…”