Specific Features of the Spread of Tuberculosis in Russia at the End of the 20th Century

Shilova, M.V.

doi:10.1111/j.1749-6632.2001.tb11369.x

Cited by 21 publications

(6 citation statements)

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“…To improve treatment outcome of TB patients and hence to achieve country wise milestone goals, understanding the attributable factors for TB mortality and identifying mortality determinants remain indispensable to find out strategies and interventions to solve the problem. Accordingly, deterioration in TB healthcare services and increase in MDR and XRD resistances were facilitators of mortality due to TB [ 4 , 5 ]. On the other hand, antiretroviral therapy (ART), cotrimoxazole preventive therapy (CPT), and type of TB diagnosis were found to be predictors of TB mortality [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Time to death and risk factors among tuberculosis patients in Northern Ethiopia

et al. 2018

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ObjectiveThe main objective of this study was to assess time to death and associated risk factors among tuberculosis (TB) patients.ResultsA total of 769 TB patients were studied and of those, 87 (11.3%) patients died. All of the deaths occurred within 7 months of anti-tuberculosis therapy. Extra-pulmonary TB (AHR = 17.376, 95% CI; 3.88–77.86, p < 0.001) as compared to pulmonary TB and cotrimoxazole prophylaxis therapy (CPT) (AHR = 0.15, 95% CI; 0.03–0.74, p = 0.02) were found to be the predictors of mortality. We noticed higher rates of mortality. Extra-pulmonary TB patients have high risk and TB-HIV co-infected patients who received CPT have low risk of death. Improving early diagnosis of extra-pulmonary TB and early CPT initiation of TB-HIV co-infected patients could minimize patient’s mortality.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3806-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Time to death and risk factors among tuberculosis patients in Northern Ethiopia

et al. 2018

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“…TB mortality has been variously attributed to a dramatic rise in drug resistance [6] and to deteriorations in TB services [7,8] and the risk of dying could be reduced through improved care [9,10]. So to avert the problem of TB mortality, policy makers should devise a plan, with clear reflection on the magnitude of mortality and associated risks factors of TB, to improve the quality and standard of TB care.…”

Section: Introductionmentioning

confidence: 99%

Mortality and associated risk factors in a cohort of tuberculosis patients treated under DOTS programme in Addis Ababa, Ethiopia

et al. 2011

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BackgroundTuberculosis (TB) is the leading cause of mortality among infectious diseases worldwide. Ninty five percent of TB cases and 98% of deaths due to TB occur in developing countries. Globally, the mortality rate has declined with the introduction of effective anti TB chemotherapy. Nevertheless, some patients with active TB still die while on treatment for their disease. In Ethiopia, little is known on survival and risk factors for mortality among a cohort of TB patients. The objective of the study is to determine the magnitude and identify risk factors associated with time to death among TB patients treated under DOTS programme in Addis Ababa, Ethiopia.MethodsThis is a retrospective cohort study. Data was obtained by assessing medical records of TB patients registered from June 2004 to July 2009 G.C and treated under the DOTS strategy in three randomly selected health centers. A step-wise multivariable Cox's regression model and Kaplan- Meier curves were used to model the outcome of interest. Mortality was used as an outcome measure. Person-years of observation (PYO) were calculated from the date of starting anti-TB treatment to date of outcome and was calculated as the number of deaths/100 PYO. Statistical analysis SPSS version 16 was used for data analysis and results were reported significant whenever P-value was less than 5%.ResultsFrom a total of 6,450 registered TB patients 236(3.7%) were died. More than 75% death occurred within eight month of treatment initiation. The mean and median times of survival starting from the date of treatment initiation were 7.2 and 7.9 months, respectively. Comparison of survival curves using Kaplan Meier curves method with log-rank test showed that the survival status was significantly different between patient categories as well as across treatment centers (P < 0.05). The death rate of pulmonary positive, pulmonary negative and extra pulmonary TB patients were 2.7%, 3.6%, and 4.3%, respectively. Body weight at initiation of anti-TB treatment (<35 kg), patient category, year of enrollment and treatment center were independent predictors for time to death.ConclusionsMost of the patients were died at the end of treatment period. This underlines the need for devising a mechanism of standardizing the existing DOTS programme and nutritional support for underweight patients for better clinical and treatment outcome.

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“…There are studies available that have analyzed factors associated to death from tuberculosis as the underlying cause and as a result found predictors of death conditions related to the deterioration of health services, increased resistance to TB, use of antiretroviral therapy, cotrimoxazole preventive therapy (CPT), and type of TB diagnosis [5,6]. Thus, existing knowledge points out that risk factors are related to the occurrence of TB, and the sociodemographic and structural characteristics of services in the region.…”

Section: Introductionmentioning

confidence: 99%