Time to death and risk factors among tuberculosis patients in Northern Ethiopia

Asgedom, Solomon Weldegebreal; Tesfaye, Daniel; Nirayo, Yirga Legesse; Atey, Tesfay Mehari

doi:10.1186/s13104-018-3806-7

Cited by 15 publications

(23 citation statements)

References 24 publications

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“…In order to achieve the 2025 global milestone for reductions in TB deaths, a CFR of 6% or less is required by all NTPs [2]. The 13% overall CFR estimated in this present study compares favourably with what a previous South African study found (16.3%) in a 10-year electronic record review [33] and in Zimbabwe (22%) [34] but higher than findings reported in Ethiopia [35,36], Cape Town (3.7%) [37], Washington state, US (12.1%) [38] and Taiwan (12.3%) [39]. The differences in CFR in different settings might be due to the differences in the study sites, study period, the study design, and target population.…”

Section: Trends and Predictors Of Tb Mortalitysupporting

confidence: 46%

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Trends of tuberculosis case detection, mortality and co-infection with HIV in Ghana: A retrospective cohort study

2020

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Background In an era of renewed commitment to accelerate the declines in Tuberculosis (TB) incidence and mortality, there is the need for National Tuberculosis Programmes (NTPs) to monitor trends in key indicators across a geographical location and to provide reliable data for direct measurement of TB incidence and mortality. In this context, we explored the trends of TB case detection, mortality and HIV co-infection, and examined the predictors of TB deaths in Ten districts of the Volta region of Ghana. Methods We conducted a retrospective cohort study of all TB cases registered from 2013 to 2017 in 10 districts of the Volta Region of Ghana. Case detection rate (CDR) was computed as the ratio of the number of new and relapse TB case notified to NTP to the number of estimated incident TB cases in a given year. Case fatality rates were estimated using data from 2012-2016 cohort of TB patients. Simple and multiple logistic regression were used to identify predictors of TB deaths with odds ratios and 95% confidence intervals estimated. Results Overall, there were 3,735 new and relapse TB patients who commenced anti-TB treatment during the period, representing the case detection rate of 40.1% with district variations. The CDR remained stable during the 5 years. Of the total cases, HIV status was documented for 3,144 (84.2%), among whom, 712 (22.6%) were HIV positive. The TB/HIV co-infection was more prevalent among children under 15 years of age (30.1%), males (30.6%), treatment after lost to follow-up patients (33.3%), and smear-negative pulmonary TB patients (29.1%). The prevalence of TB/HIV co-infection did not significantly change over the years. The overall case fatality rate was 13% (n = 486), with considerable variation among HIV-positives and HIV-negative TB patients (21.8% and 11% respectively) (p<0.001) and among districts.

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Section: Trends and Predictors Of Tb Mortalitysupporting

confidence: 46%

“…[44,45]. Studies from different populations [35,46,47] have also shown that TB/HIV co-infected patients who were not taking CPT were at highest risk of death. This study, however, did not have the data to confirm or refute this claim.…”

Section: Trends and Predictors Of Tb Mortalitymentioning

confidence: 99%

Trends of tuberculosis case detection, mortality and co-infection with HIV in Ghana: A retrospective cohort study

2020

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“…However, the relevant departments cannot relax their vigilance and further measures are needed to strengthen the tracking, follow-up, and management of male, elderly, HIV-positive, retreated, and smear-positive TB patients, to further improve the treatment success rate. Focusing on adverse reactions and complications in administering antituberculosis treatment at an early stage will help improve the antiviral treatment effect and reduce the mortality rate [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Survival Analysis of Risk Factors for Mortality in a Cohort of Patients with Tuberculosis

Xie

Han

et al. 2020

Canadian Respiratory Journal

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Identify the treatment effects and risk factors for mortality in patients with pulmonary tuberculosis receiving antituberculosis treatment under the Directly Observed Treatment Short-Course (DOTS) program to reduce the mortality rate of tuberculosis. A retrospective cohort analysis was conducted on the outcomes of antituberculosis treatment of 7,032 patients with tuberculosis in the DOTS program, in the Tuberculosis Management Information System from 2014 to 2017 in Tianjin, China. The Kaplan–Meier method and multifactor Cox proportional risk regression model were used to analyze the risk factors for mortality during antituberculosis treatment under DOTS. The success rate of antituberculosis treatment was 90.24% and the mortality rate was 4.56% among 7,032 cases of tuberculosis in Tianjin. Cox regression analysis showed that advanced age, male sex, human immunodeficiency virus (HIV) positivity, first sputum positivity, retreated tuberculosis, and a delayed visit (≥14 days) were risk factors for mortality in patients with pulmonary tuberculosis receiving antituberculosis treatment under DOTS. The treatment effects in patients with pulmonary tuberculosis during antituberculosis treatment under DOTS were positive in Tianjin. Advanced age, male sex, HIV positivity, first sputum positivity, retreated tuberculosis, and a delayed visit (≥14 days) increased the risk for mortality during antituberculosis treatment.

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“…Direct involvement of different risk factors for this dilemma are the distinct reason of increasing infection susceptibility, and PTB progression 15,16. These factors also play vital role in prediction of mortality in PTB patients, such as increasing age, poor health care facilities due to poverty, low income, anemia, CLD, DM, HIV, HTN, recurrent TB, and smoking 17,18…”

Section: Discussionmentioning

confidence: 99%

Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

Hameed

Zuberi²,

Hussain

et al. 2019

Pak J Med Sci

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Objective: To evaluate risk factors having significant effect on mortality of smear positive Pulmonary Tuberculosis (PTB) inpatients. Methods: A descriptive cross-sectional study was conducted at Ojha Institute of Chest Diseases, Dow University Hospital Ojha Campus, Karachi. One hundred and seventy (170) inpatients of smear positive PTB confirmed by Acid Fast Bacilli (AFB) smear, aged between 13-80 years were enrolled by using consecutive sampling technique while patients with drug resistant Tuberculosis (TB) and extra pulmonary TB were excluded from the study. Selected patients were interviewed for collecting demographic data and risk factor data by using a standard questionnaire. Results: Out of 170 PTB inpatients, mortality was observed in 23 (13.5%) patients among which male patients were 12 (52.2%), and female were 11 (47.8%). Mortality was significantly associated with increasing age (p=0.003), socioeconomic status (p=0.019), anemia (p=0.03), Chronic Liver Disease (CLD) (p=0.005), Diabetes Mellitus (DM) (p=0.001), Human Immunodeficiency Virus (HIV) (p=0.007), Hypertension (HTN) (p=0.006), recurrent TB (p=0.001), and smoking (p=0.001). Conclusion: Increasing age, poverty, smoking history, and presence of comorbidities like DM, CLD, HIV, hypertension, and anemia are associated with higher mortality in smear positive PTB cases. doi: https://doi.org/10.12669/pjms.35.5.919 How to cite this:Hameed S, Zuberi FF, Hussain S, Ali SK. Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.919 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Time to death and risk factors among tuberculosis patients in Northern Ethiopia

Cited by 15 publications

References 24 publications

Trends of tuberculosis case detection, mortality and co-infection with HIV in Ghana: A retrospective cohort study

Trends of tuberculosis case detection, mortality and co-infection with HIV in Ghana: A retrospective cohort study

Survival Analysis of Risk Factors for Mortality in a Cohort of Patients with Tuberculosis

Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

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