Special Issue: Natural Products: Anticancer and Beyond

Cui, Qingbin; Yang, Dong‐Hua; Chen, Zhe‐Sheng

doi:10.3390/molecules23061246

Cited by 21 publications

(18 citation statements)

References 24 publications

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“…Second, as polyphenolic compounds, many flavonoids may work as ROS modulators (18) as they affect the status of ROS level in cancer cells (232). Under different dose, they may work either as ROS scavengers or inducer.…”

Section: Discussion and Future Perspectivementioning

confidence: 99%

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Shen

et al. 2019

Front. Oncol.

115

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Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have been developed, but most of them fail in clinical trials due to severely adverse effects. Recently, certain natural products have been reported to overcome MDR, including flavonoids which are abundant in plants, foods, and herbs. The structure of flavonoids can be abbreviated as C6-C3-C6 (C for carbon), and further categorized into flavonoids, iso-flavonoids and neo-flavonoids, according to their structural backbones. Flavonoids possess multiple bioactivities, and a growing body of research has indicated that both flavonoids and iso-flavonoids can either kill or re-sensitize conventional chemotherapeutics to resistant cancer cells. Here, we summarize the research and discuss the underlying mechanisms, concluding that these flavonoids do not function as specific regulators of target proteins, but rather as multi-functional agents that negatively regulate the key factors contributing to MDR.

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Section: Discussion and Future Perspectivementioning

confidence: 99%

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Shen

et al. 2019

Front. Oncol.

115

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“…Natural products with a low risk of side effects and good efficacy are attractive sources of therapeutic drug compounds used for the prevention and treatment of chronic diseases . As a potent saponin isolated from the classical traditional Chinese medicine Platycodonis Radix , platycodin D has previously been confirmed to have potential antitumor, anti‐inflammatory, and immunomodulatory effects .…”

Section: Discussionmentioning

confidence: 99%

Stimulatory effects of platycodin D on osteoblast differentiation

Han

Jin

Lee

et al. 2019

J of Cellular Biochemistry

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Previous studies have suggested that platycodin D is implicated in bone biology and ameliorates osteoporosis development. Platycodin D repressed the osteoclast activity and enhanced bone mineral density in the mouse model. However, the effects of platycodin D on osteoblast differentiation have not been elucidated yet. In C3H10T1/2 cells, platycodin D upregulated osteogenic markers including alkaline phosphatase (ALP), bone sialoprotein, and collagen type 1 alpha 1, and transcription factors, such as Runx2 and osterix, subsequently enhancing the bone mineralization. In a molecular mechanism study, platycodin D induced β-catenin nuclear accumulation by upregulating GSK3β phosphorylation. Furthermore, platycodin D upregulated the ALP activity and enhanced the mineralization process in osteoblast cells via the sirtuin 1/β-catenin pathways. Taken together, these results suggested that platycodin D could be an effective therapeutic compound against osteoporosis because of its regulatory effects during the osteoblast differentiation.

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“…Natural products play a relevant role in cancer therapy, with a substantial number of natural anticancer agents (Rayan et al, 2017;Blowman et al, 2018;Cui et al, 2018). Furthermore, because cancer treatments have become more aggressive during the last 20 years, the need for new methods to manage adverse and/or side effects of such therapy has become apparent (Redd et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

Bastos¹,

Costa²,

Valois³

et al. 2018

J. Med. Plants Res.

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Punica granatum, specifically the fruit, has a long ethno medical history and is a phytochemical reservoir of great medicinal value. The phytochemistry and pharmacological actions of all P. granatum components suggest a wide range of clinical applications. The aim of the present study is to investigate the anticancer potential of aqueous extract of P. granatum (AEPG) in experimental models. The chemical composition of the AEPG was assessed by HPLC-DAD. In vivo antitumor activity was assessed in sarcoma 180 bearing mice. To evaluate the toxicological aspects related to the AEPG treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were performed. Gallic acid, punicalagin α, punicalagin β, and ellagic acid were identified as the major phytochemical compounds of the extract. AEPG and 5-fluorouracil (5-FU) induced significant inhibition of tumor growth when compared with saline (p < 0.05). The percentage of apoptotic cells was significantly increased in 5-FU (p < 0.01) and AEPG treated groups (p < 0.01). No significant difference was observed between 5-FU and the three doses of AEPG. 5-FU induced toxic effects, such as decrease of body weight, splenic atrophy, and leukopenia, but these effects were not found in AEPG treated groups. The results provide evidence that AEPG exhibits comparable antitumor effects as 5-FU in a murine model, likely the result of increased apoptotic rate, but with no remarkable side effects presented by 5-FU.

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Special Issue: Natural Products: Anticancer and Beyond

Abstract: n/a

Cited by 21 publications

References 24 publications

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Stimulatory effects of platycodin D on osteoblast differentiation

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

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