Stimulatory effects of platycodin D on osteoblast differentiation

Abstract

Previous studies have suggested that platycodin D is implicated in bone biology and ameliorates osteoporosis development. Platycodin D repressed the osteoclast activity and enhanced bone mineral density in the mouse model. However, the effects of platycodin D on osteoblast differentiation have not been elucidated yet. In C3H10T1/2 cells, platycodin D upregulated osteogenic markers including alkaline phosphatase (ALP), bone sialoprotein, and collagen type 1 alpha 1, and transcription factors, such as Runx2 and osterix, subsequently enhancing the bone mineralization. In a molecular mechanism study, platycodin D induced β-catenin nuclear accumulation by upregulating GSK3β phosphorylation. Furthermore, platycodin D upregulated the ALP activity and enhanced the mineralization process in osteoblast cells via the sirtuin 1/β-catenin pathways. Taken together, these results suggested that platycodin D could be an effective therapeutic compound against osteoporosis because of its regulatory effects during the osteoblast differentiation.

Platycodin D inhibits the proliferation, invasion and migration of endometrial cancer cells by blocking the PI3K/Akt signaling pathway via ADRA2A upregulation

“…Platycodin D (PD), a triterpenoid saponin extracted from the roots of Platycodin grandiflorum, has been reported to possess anticancer effects in several cancer cell lines, including lung, gastric and prostate cancer cells (6). PD has been shown to suppress the tumor growth of breast cancer cells in vitro and in vivo via the inhibition of mouse double minute 2 homolog and mutated p53 in MDA-MB-231 cells (7).…”

Effect of Developmental Stages on the Biosynthesis of Triterpene Saponins and Related Gene Expression in Seedlings of Platycodon grandiflorus

“…4 Among these, triterpenoid saponins, such as Platycodin A, Platycodin B, and Platycodin D are considered to be the key bioactive compounds due to their anti-inflammatory and immune-enhancing pharmacological properties. 5–7 Notably, Platycodin D has gained significant attention from researchers due to its therapeutic effects 8–10 (Figure 1).…”