Spatial memory alterations by activation of septal 5HT1A receptors: no implication of cholinergic septohippocampal neurons

Koenig, Julie; Lecourtier, Lucas; Cosquer, Brigitte; Pereira, Patricia Marques; Cassel, Jean‐Christophe

doi:10.1007/s00213-010-2049-7

Cited by 12 publications

(3 citation statements)

References 59 publications

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“…In addition, the strongest argument for a role of the HF in the control of spatial memory was provided by the discovery of ''place cells '' there (O'Keefe and Dostrovsky, 1971). Koenig et al (2011) postulated that, in the MS, the three neuronal populations (GABAergic, glutamatergic and cholinergic) could cooperate to process hippocampus-dependent information, and that noncholinergic septo-hippocampal neurons might be more important than are those that are cholinergic in serotonin-induced modulation of hippocampus-dependent memory processing. Kirby and Rawlins (2003) showed that there was no impairment in the spatial working memory of rats at seven days after lesion of the cholinergic neurons in the MS, although the rats were trained before the lesion.…”

Section: Neurochemical Aspectsmentioning

confidence: 99%

Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat

Lima¹,

Sita²,

Oliveira³

et al. 2013

Journal of Chemical Neuroanatomy

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Section: Neurochemical Aspectsmentioning

confidence: 99%

Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat

Lima¹,

Sita²,

Oliveira³

et al. 2013

Journal of Chemical Neuroanatomy

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“…A combined sigma/5-HT 1A receptors agonist, OPC-14523, reverses scopolamine-and age-associated learning and memory deficits in passive avoidance or Morris water maze (MWM) (Tottori et al 2002). These effects might be mediated by an increase in ACh release in dorsal hippocampus (DH;Tottori et al 2002), although some studies demonstrated that noncholinergic neurons might play the main role in serotonin effects on hippocampal memory processing (Koenig et al 2011). Subcutaneous (s.c.) administration of 5-HT 1B receptor (5-HT 1B R) agonists impairs memory retention in onetrial PA.…”

Section: The Effects Of Serotonin On Cholinergic Transmissionmentioning

confidence: 99%

The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

et al. 2014

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Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT1-7), each with several subpopulations, have been identified for serotonin, which are different in terms of localization and downstream signaling. Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years. A large body of evidence indicates the interplay between serotonergic transmission and other neurotransmitters including acetylcholine, dopamine, γ-aminobutyric acid (GABA) and glutamate, in the neurobiological control of learning and memory. In addition, there has been an alteration in the density of serotonergic receptors in aging and Alzheimer's disease, and serotonin modulators are found to alter the process of amyloidogenesis and exert cognitive-enhancing properties. Here, we discuss the serotonin-induced modulation of various systems involved in mnesic function including cholinergic, dopaminergic, GABAergic, glutamatergic transmissions as well as amyloidogenesis and intracellular pathways.

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“…Multiple serotonin receptor subtypes have been found to be expressed in the BNST, to include 1A, 2A, 1B, 2C and 7 subtypes (Hazra, et al, 2012). Expression of serotonin receptors 1A (Koenig, et al, 2011), 2A (de Paula, et al, 2012 and type 3 (Urzedo-Rodrigues, et al, 2014) has been reported in the septum, while the subtypes 1A (Sun, et al, 2015) and 2C (Scopinho, et al, 2012) are expressed in the MeA.…”

Section: Septum Amygdala Bnst and Mesencephalonmentioning

confidence: 99%

Neuroanatomical dichotomy of sexual behaviors in rodents

Angoa‐Pérez

Kuhn

2015

Behavioural Pharmacology

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Much of the social behavior in which rodents engage is related to reproduction, such as maintaining a breeding territory, seeking mates, mating, and caring for their young. Rodents belong to the internally fertilizing species that require sexual behavior for reproduction. The dyadic, heterosexual patterns of most mammalian species are sexually dimorphic, but they also share mutual components in both sexes: sexual attraction is reciprocal, sexual initiative is assumed, appetitive behavior is engaged in, and mating involves consummatory and postconsummatory phases in females as well as in males. Serotonin, a phylogenetically ancient molecule, is the most widely distributed neurotransmitter in the brain and its signaling pathways are essential for numerous functions including sexual behavior. Since the late 1960s, brain serotonergic neurotransmission has been considered to exert an inhibitory influence on the neural mechanisms mediating sexual behavior. This contention was based mainly on the observations that a decrease in central serotonergic activity facilitated the elicitation of sexual behavior, whereas an increase in central serotonergic activity attenuated it. However, the discovery of over 14 types of serotonin receptors has added numerous layers of complexity to the study of serotonin and sexual behavior. Evidence shows that, upon activation, certain receptor subtypes facilitate, whereas some others suppress, sexual behavior, as well as sexual arousal and motivation. Furthermore, the role of these receptors has been shown to be different in the male and female sexes. The use of serotonergic pharmacological interventions, mouse strains with genetic polymorphisms causing alterations in the levels of brain serotonin, and animal models with genetic manipulations of various serotonin effectors has helped delineate the fundamental role of this neurotransmitter in the regulation of sexual behavior. This review aims to examine the basics of the components of female and male sexual behavior and the participation of the serotonin system in the modulation of these behaviors, with emphasis on rodents.

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Spatial memory alterations by activation of septal 5HT1A receptors: no implication of cholinergic septohippocampal neurons

Cited by 12 publications

References 59 publications

Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat

Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat

The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

Neuroanatomical dichotomy of sexual behaviors in rodents

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