Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat

Lima, Fernando Fusari Bento de; Sita, Luciane V.; Oliveira, Amanda Ribeiro de; Costa, Helder C.; Silva, Joelcimar M. da; Mortara, Renato Arruda; Haemmerle, Carlos Alexandre dos Santos; Xavier, Gilberto Fernando; Canteras, Newton S.; Bittencourt, Jackson Cioni

doi:10.1016/j.jchemneu.2012.10.003

Cited by 23 publications

(15 citation statements)

References 93 publications

(105 reference statements)

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“…Neuroscience 289 (2015) 392-405 [MCH-ir] neuronal projections spread throughout the entire CNS, which corroborates the functional diversity of MCH (Bittencourt et al, 1992;Lima et al, 2013). Furthermore, MCH receptor type 1 [MCH1R] mRNA mapping studies (Saito et al, 2001) primarily correlated the mRNA distribution with areas previously described as receiving MCH-ir axonal projections.…”

Section: Introductionsupporting

confidence: 66%

Melanin-concentrating hormone inputs to the nucleus accumbens originate from distinct hypothalamic sources and are apposed to GABAergic and cholinergic cells in the Long-Evans rat brain

2015

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Section: Introductionsupporting

confidence: 66%

Melanin-concentrating hormone inputs to the nucleus accumbens originate from distinct hypothalamic sources and are apposed to GABAergic and cholinergic cells in the Long-Evans rat brain

2015

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“…If MCH neurons contact these hypothalamic GABA cells, the optogenetic activation of MCH could indirectly disinhibit the RT resulting in higher NREM sleep and EEG delta power. MCH neurons project throughout the brain, innervating neuronal populations implicated in waking and REMS (Cvetkovic et al, 2003(Cvetkovic et al, , 2004Hanriot et al, 2007;Sita et al, 2007;Croizier et al, 2010;Hong et al, 2011;Lima et al, 2013;Torterolo et al, 2013;Yoon & Lee, 2013). It is not known whether a single MCH neuron projects to multiple ascending and descending targets, but the MCH neurons located in the lateral cluster project primarily to the pons, where REMS generator neurons are located (Cvetkovic et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Optogenetic activation of melanin‐concentrating hormone neurons increases non‐rapid eye movement and rapid eye movement sleep during the night in rats

Blanco-Centurión

Konadhode

et al. 2016

Eur J of Neuroscience

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Neurons containing melanin-concentrating hormone (MCH) are located in the hypothalamus. In mice optogenetic activation of the MCH neurons induces both NREM and REM sleep at night, the normal wake-active period for nocturnal rodents (Konadhode et al., 2013). Here we selectively activate these neurons in rats to test the validity of the sleep network hypothesis in another species. Channelrhodopsin-2 (ChR2) driven by the MCH promoter was selectively expressed by MCH neurons after injection of rAAV-MCHp-ChR2-EYFP into the hypothalamus of Long-Evans rats. An in vitro study confirmed that the optogenetic activation of MCH neurons faithfully triggered action potentials. In the second study, in Long-Evans rats, rAAV-MCH-ChR2, or the control vector, rAAV-MCH-EYFP, were delivered into the hypothalamus. Three weeks later baseline sleep was recorded for 48h without optogenetic stimulation (0 Hz). Subsequently, at the start of the lights-off cycle, the MCH neurons were stimulated at 5, 10, or 30Hz (1 mW at tip; 1 min on – 4 min off) for 24 h. Sleep was recorded during the 24h stimulation period. Optogenetic activation of MCH neurons increased both REM and NREM sleep at night, whereas during the day cycle only REM sleep was increased. Delta power, an indicator of sleep intensity, was also increased. In control rats without ChR2, optogenetic stimulation did not increase sleep or delta power. These results lend further support to the view that sleep-active MCH neurons contribute to drive sleep in mammals.

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“…The HF has been thoroughly implicated in memory (Scoville and Milner, 1957; Zola-Morgan et al, 1986; Squire, 1992) and is one of the major targets of MCH-ir fibers and MCHR1 synthesis in the rat brain (Bittencourt et al, 1992; Hervieu et al, 2000; Saito et al, 2001). Lima et al (2013) provided a more detailed description of the MCH input to the HF, describing a higher density of MCH-ir fibers in the dorsal HF, especially in the CA3 field, and the presence of MCH-ir fibers plexuses around GABAergic basket cells in CA1 and CA3, in addition to apparent contacts between MCH-ir fibers and HF-projecting cholinergic cells of the MS.…”

Section: Feeding Behaviormentioning

confidence: 99%

The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors

Diniz

Bittencourt

2017

Front. Syst. Neurosci.

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The melanin-concentrating hormone (MCH) is an important peptide implicated in the control of motivated behaviors. History, however, made this peptide first known for its participation in the control of skin pigmentation, from which its name derives. In addition to this peripheral role, MCH is strongly implicated in motivated behaviors, such as feeding, drinking, mating and, more recently, maternal behavior. It is suggested that MCH acts as an integrative peptide, converging sensory information and contributing to a general arousal of the organism. In this review, we will discuss the various aspects of energy homeostasis to which MCH has been associated to, focusing on the different inputs that feed the MCH peptidergic system with information regarding the homeostatic status of the organism and the exogenous sensory information that drives this system, as well as the outputs that allow MCH to act over a wide range of homeostatic and behavioral controls, highlighting the available morphological and hodological aspects that underlie these integrative actions. Besides the well-described role of MCH in feeding behavior, a prime example of hypothalamic-mediated integration, we will also examine those functions in which the participation of MCH has not yet been extensively characterized, including sexual, maternal, and defensive behaviors. We also evaluated the available data on the distribution of MCH and its function in the context of animals in their natural environment. Finally, we briefly comment on the evidence for MCH acting as a coordinator between different modalities of motivated behaviors, highlighting the most pressing open questions that are open for investigations and that could provide us with important insights about hypothalamic-dependent homeostatic integration.

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Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat

Cited by 23 publications

References 93 publications

Melanin-concentrating hormone inputs to the nucleus accumbens originate from distinct hypothalamic sources and are apposed to GABAergic and cholinergic cells in the Long-Evans rat brain

Melanin-concentrating hormone inputs to the nucleus accumbens originate from distinct hypothalamic sources and are apposed to GABAergic and cholinergic cells in the Long-Evans rat brain

Optogenetic activation of melanin‐concentrating hormone neurons increases non‐rapid eye movement and rapid eye movement sleep during the night in rats

The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors

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