The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

Seyedabadi, Mohammad; Fakhfouri, Gohar; Ramezani, Vahid; Mehr, Shahram Ejtemaei; Rahimian, Reza

doi:10.1007/s00221-013-3818-4

Cited by 109 publications

(67 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, serotonergic effects on hippocampus are indirect and intricate. Depending on the type of receptor, serotonin agonists may increase or decrease memory performance in laboratory animals and many of these effects also involve the modification of cholinergic, dopaminergic, GABAergic or glutamatergic transmission (Seyedabadi et al, 2014). In human experiments, central serotonin depletion impairs the encoding, delayed but not immediate recall, as well as delayed recall of source episodic memory in a verbal learning task.…”

Section: Box 2: Role Of Sleep In the Consolidation And Generalizationmentioning

confidence: 99%

Influence of reward motivation on human declarative memory

Miendlarzewska

Bavelier

Schwartz

2016

Neuroscience & Biobehavioral Reviews

149

134

View full text Add to dashboard Cite

a b s t r a c tMotivational relevance can prioritize information for memory encoding and consolidation based on reward value. In this review, we pinpoint the possible psychological and neural mechanisms by which reward promotes learning, from guiding attention to enhancing memory consolidation. We then discuss how reward value can spill-over from one conditioned stimulus to a non-conditioned stimulus. Such generalization can occur across perceptually similar items or through more complex relations, such as associative or logical inferences. Existing evidence suggests that the neurotransmitter dopamine boosts the formation of declarative memory for rewarded information and may also control the generalization of reward values. In particular, temporally-correlated activity in the hippocampus and in regions of the dopaminergic circuit may mediate value-based decisions and facilitate cross-item integration. Given the importance of generalization in learning, our review points to the need to study not only how reward affects later memory but how learned reward values may generalize to related representations and ultimately alter memory structure.

show abstract

Section: Box 2: Role Of Sleep In the Consolidation And Generalizationmentioning

confidence: 99%

Influence of reward motivation on human declarative memory

Miendlarzewska

Bavelier

Schwartz

2016

Neuroscience & Biobehavioral Reviews

149

134

View full text Add to dashboard Cite

show abstract

“…Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT1-7), each with several subpopulations, have been identified for serotonin, which are different in terms of localization and downstream signalling [83]. Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years.…”

Section: Antidepressive Agentsmentioning

confidence: 99%

“…Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years. A large body of evidence indicates the interplay between serotonergic transmission and other neurotransmitters including acetylcholine, dopamine, γ-aminobutyric acid (GABA) and glutamate, in the neurobiological control of learning and memory [83].…”

Section: Antidepressive Agentsmentioning

confidence: 99%

Neuroenhancement in Healthy Adults, Part I: Pharmaceutical Cognitive Enhancement: A Systematic Review

Micoulaud¹

2015

J Clinic Res Bioeth

View full text Add to dashboard Cite

The term neuroenhancement refers to improvement in the cognitive, emotional and motivational functions of healthy individuals through inter alia, the use of drugs. This popular topic attracts attention both from the general public and the scientific community. Our objective is to summarize in a synthetic review the data of randomized placebo-controlled trials that assessed cognitive effects of administration of neuroenhancers in non-sleep-deprived healthy adults compared to placebo. The major outcomes were attention, memory, learning, executive functions, and vigilance/wakefulness. Details on the pharmacological profile, effectiveness and safety for each drug are provided. We classify them according to their recognized major primary mode of action, namely catecholaminergics (methylphenidate,

show abstract

“…Serotonin (5-Hydroxytriptamine, 5-HT) neurons have been extensively involved in the regulation of mood 1 , sleep 2 , learning 3 , memory 4 , cognition 5 and impulsivity 6 . As such, the functional connectivity of 5-HT neurons within the brain is complex and remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Excitatory/inhibitory balance of serotonergic axon connectivity in the brain

Belmer¹

2016

J Neurol Neuromedicine

View full text Add to dashboard Cite

Serotonin neurons originate from the brainstem raphe nuclei and innervate the entire brain to regulate mood, emotion, sleep, appetite and aggression. Previous electron microscopy (EM) studies have revealed that 5-HT boutons directly contact several neuronal populations via asymmetrical (excitatory) or symmetrical (inhibitory) synapses. Additionally, 5-HT boutons sometimes form "triads" with the pre and postsynaptic components of asymmetrical or symmetrical synapses to modulate their activity. However, the exact proportion and distribution of 5-HT excitatory/inhibitory synapses and triads within the entire brain remains poorly described. Recently, we have published a novel semi-quantitative approach which combines fluorescent confocal microscopy and 3D reconstruction of 5-HT fibers apposed to excitatory and inhibitory neurochemical synapses (triads). Here, we review the similarities and differences in the distribution of 5-HT asymmetrical/symmetrical synapses observed in EM and the distribution of 5-HT excitatory/inhibitory triads quantified in our recent study. We further put into perspective the possible physiological role played by 5-HT triads in the regulation of glutamate and GABA signaling in these various brain regions.

show abstract

The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

Cited by 109 publications

References 170 publications

Influence of reward motivation on human declarative memory

Influence of reward motivation on human declarative memory

Neuroenhancement in Healthy Adults, Part I: Pharmaceutical Cognitive Enhancement: A Systematic Review

Excitatory/inhibitory balance of serotonergic axon connectivity in the brain

Contact Info

Product

Resources

About