Spasmolytic Effects of Nonprenylated Rotenoid Constituents of Boerhaavia diffusa Roots

Abstract

Boerhaavia diffusa is an Ayurvedic remedy used traditionally for the treatment of a number of diseases, including those affecting the gastrointestinal tract. In the current investigation, a methanol extract obtained from roots of B. diffusa exhibited a significant spasmolytic activity in the guinea pig ileum, probably through a direct effect on the smooth muscle. A detailed phytochemical analysis of this methanol extract led to the isolation of one new (12) and six known (6-11) rotenoid derivatives. The structure of the new compound was determined through interpretation of its MS and NMR data. All the isolated rotenoids were evaluated for their effect on intestinal motility in vitro, and the results obtained showed unambiguously that they are active spasmolytic constituents. Preliminary structure-activity relationships for this class of compounds are suggested.

Advances in Boerhaavia diffusa hairy root technology: a valuable pursuit for identifying strain sensitivity and up-scaling factors to refine metabolite yield and bioactivity potentials

“…The latest discoveries of the potential anticancer, immunomodulatory and radioprotective activity of B. diffusa have highlighted its beneficial efficacies in cancer therapy (Mishra et al 2014). Demonstration of antispasmodics/spasmolytic activity of the methanolic root extracts of this plant has further shown the potent use of this time-honoured medicinal plant for the treatment of involuntary muscle spasm caused due to various muscle disorders, including the debilitating symptoms of torticollis, paraplegia and palsy/glossal palsy (Borrelli et al 2006;Mishra et al 2014). A recent report has ignited new expectations about the cardio-protective potential of the ethanolic extract B. diffusa by highlighting its efficacious impact against mitochondrial dysfunction, which has formerly been proven to play a crucial role in triggering the development of cardiac hypertrophy and heart failure (Prathapan et al 2014).…”

New Rotenoids and Coumaronochromonoids from the Aerial Part of <i>Boerhaavia erecta</i>

“…Among those ten were rapidly identified as boeravinone G (1), 12) boeravinone H (2), 12) boeravinone C (4), 13) 10-demethylboeravinone C (5), 14) boeravinone J (7), 15) cucumegastigmane (9), 16) isovitexin (12), 17) quercetin 3-O-β-d-glucopyranoside (13), 18) isorhamnetin 3-O-α-l-rhamnopyranosyl-(1→ 6)-β-d-glucopyranoside (14), 18) and kaempferol 3-O-α-l-rhamnopyranosyl-(1→ 6)-β-dglucopyranoside (15) 18) ( Fig. 1) by comparison of their spectral data with those reported in the literature.…”

“…5) The 13 C-NMR spectrum ( −339 (c=1.1, MeOH)}, isolated from B. diffusa 14) and B. coccinea, 26) although there was a disparity in the optical rotation values. Based on the 2D-NMR data (Fig.…”

Pharmacological study of antispasmodic activity of Mirabilis jalapa Linn flowers

“…Meanwhile, further scientific research is needed to elucidate the mechanism of action of the different chemical components contained within Mirabilis jalapa, such as boeravinone and ␤-sitosterol-␤-d-glucoside, which have been reported to be spasmolytic (Khan and Shoeb, 1985;Borrelli et al, 2006). This will aid in the understanding of the curative properties of this plant in ailments such as abdominal colic, diarrhea, and dysentery, among others.…”