Soy husk extract improves physical and biochemical parameters of obese–diabetic rats through the regulation of PPARγ expression

Abstract

Unhealthy eating habits and lack of physical activities are among the contributing factors for obesity and diabetes. It has been reported that consumption of naturally occurring phenolics could exert beneficial effects toward these diseases. Therefore, this study aims to evaluate the ability of phenolic‐rich soy husk powder extract (SHPE) in modifying the physical and biochemical parameters for obesity and diabetes. Forty‐nine Sprague Dawley rats were divided into seven groups, including three supplementary/treatment groups. Rats in supplementary/treatment groups were provided with either 4 mg/kg BW Rosiglitazone Maleate, 250 mg SHPE/kg BW, or 500 mg SHPE/kg BW. The effectiveness of SHPE in alleviating obesity–diabetes was evaluated by measuring body weight (physical parameter), blood glucose metabolisms (biochemical parameters), and PPARγ expression. Findings in the present study revealed that short‐term SHPE and Rosiglitazone Maleate administration improved the physical and biochemical parameters of obese–diabetic rats. In addition, SHPE was also demonstrated to upregulate PPARγ expression in adipocytes. These findings suggest that soy husk could emerge as a potential hypoglycemic and anti‐adipogenic nutraceutical in future. Practical applications This was the first study to evaluate the potential effects of soy husk against the parameters of obese–diabetes in rats. In addition, promising effects derived from this study might explore the possibility of soy husk to be utilized as an antidiabetes nutraceutical.

Phytochemicals derived from soya bean husk exert hypoglycemic and anti-adipogenic properties in cell culture models

“…As SHPE has been reported to contain a significant amount of gallic acid and chlorogenic acid (Appendix 2) (Tan et al , 2010), it can be postulated that the anti-adipogenic properties of soy husk was derived from these two bioactive compounds. A recent study by Tan et al (2019) showed that soya bean husk extract improved the physical and biochemical parameters of obese-diabetic rats through the regulation of PPAR γ expression. It appears that in vitro findings derived from the present study are in well-agreement with those reported in an obese-diabetes rat model.…”

Watermelon (Citrullus lanatus) leaf extract attenuates biochemical and histological parameters in high‐fat diet/streptozotocin‐induced diabetic rats

“…Given the many drawbacks of the available antidiabetic drugs, patients are looking for a safer and cheaper alternative for the treatment of diabetes mellitus. A growing body of literature recognizes the use of natural products from herbs and fruits (Adyab et al, 2019;Oyeleye et al, 2021;Tan et al, 2019;Teoh & Das, 2018). These plant extracts contain numerous active metabolites that synergistically work to reduce blood glucose and improve other metabolic complications related to diabetes mellitus (El-Abhar & Schaalan, 2014;Kar et al, 2003;Lasano et al, 2021).…”