Watermelon (<i>Citrullus lanatus</i>) leaf extract attenuates biochemical and histological parameters in high‐fat diet/streptozotocin‐induced diabetic rats

Jibril, Muhammad Mustapha; Hamid, Azizah Abdul; Abas, Faridah; Karrupan, Jeeven; Mohammed, Abdulkarim Sabo; Jaafar, Ahmad Haniff; Dek, Mohd Sabri Pak; Ramli, Nurul Shazini

doi:10.1111/jfbc.14058

Cited by 3 publications

(3 citation statements)

References 42 publications

(54 reference statements)

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“…The possible use of watermelon in the treatment of DM and in some related comorbidity diseases were explored in an in vivo study, where the extracts of the leaves of C. lanatus were administered in doses of 200 and 400 mg/kg to obese and diabetic-induced rats. The histological analysis demonstrated that the extracts of watermelon were able to attenuate the biochemical parameters and structural changes in the kidneys and liver of diabetic animals, indicating that the extract may be useful in complications associated with diabetes [ 148 ]. A different study showed that dietary supplementation with watermelon and L-citrulline reduced blood pressure in trials in humans probably plays an important role in the metabolism of lipids and in the control of satiety, consequently, watermelon could be useful in cardiac disease associated with diabetes [ 149 ].…”

Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 99%

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

et al. 2022

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In Mexico, Diabetes mellitus (DM) is a serious health problem, and although the current pharmacological treatments for DM such as insulin and oral hypoglycemics are available, the Mexican population continues to use medicinal plants in the treatment of DM. The antidiabetic properties of the plant species that belong to the Cucurbitaceae family has already been recognized worldwide. Since Mexico is one of the most important centers of diversity of Cucurbitaceae, the present work contributes to the review of the most used species of Cucurbitaceae in the treatment of DM in Mexico. The reviewed species (Cucurbita ficifolia, C. maxima, C. moschata, C. pepo, Ibervillea sonorae, Sechium edule, Citrullus lanatus, Cucumis melo, and C. sativus) revealed that the antidiabetic effects exerted are effective in a number of mechanisms involved in the complex pathogenesis of DM: hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, protective effects on diverse organs and cells, as well as in the control of dyslipidemias; furthermore, the select species of the Cucurbitaceae family could also be essential components of diets for the control of DM in patients with the disease. Thus, the Cucurbitaceae species selected in the present work represent a source of antidiabetic agents that perhaps establish the bases for novel clinical treatments.

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Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 99%

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

et al. 2022

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“…Out of the three different types of diabetes, type II diabetes mellitus is the most rampant accounting for approximately 90-95% of all global cases [4]. Insulin resistance, pancreatic beta cell dysfunction and insufficient insulin production are the characteristics hallmarks of type II diabetes mellitus [5,6]. Hyperglycaemia is the major clinical feature in diabetes and it is responsible for the multiple tissue and organ damages associated with the disease.…”

Section: Introductionmentioning

confidence: 99%

“…Hyperglycaemia is the major clinical feature in diabetes and it is responsible for the multiple tissue and organ damages associated with the disease. Hyperglycemia through oxidative-inflammatory outburst forms the pathological and physiological basis for all diabetic complications including nephropathy, neuropathy, cardiovascular diseases, retinopathy and Alzheimer's disease [6,7].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Polyphenol-Rich Fraction of Boesenbergia rotunda in Diabetic Rats: A Focus on Hypoglycemic, Antihyperlipidemic, Carbohydrate Metabolism, Antioxidant, Anti-Inflammatory and Pancreato-Protective Activities

Wang¹,

Liu²,

Shu³

et al. 2022

Front. Biosci. (Landmark Ed)

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Introduction: Boesenbergia rotunda is a famous culinary/medicinal herb native to Southeast Asia region and it is traditionally used in the treatment of several diseases. This study investigated the anti-diabetic properties of Boesenbergia rotunda polyphenol extract (BRE) in high fructose/streptozotocin-induced diabetic rats. Method: The in vitro antioxidant activity was evaluated using DPPH and ABST colorimetric assays, while the Folin-Ciocalteu method was used for the total phenolic content of BRE. For diabetes induction, a combination of high fructose solution and streptozotocin was administered to the rats and diabetic rats were orally administrated with BRE (100 and 400 mg/kg) for 5 weeks. The fasting blood glucose, body weight gain, food and water consumption were determined during the treatment period. Results: BRE showed excellent in vitro DPPH and ABTS scavenging activity with high phenolic content. BRE significantly lowered fasting blood glucose level, HbA1c, lipid profile, hepatorenal biochemical parameters and ameliorated the IPGTT in diabetic rats. Additionally, BRE reversed body weight loss, attenuated food and water intake, serum insulin level, pancreatic β-cell function and pancreatic cell morphology. Furthermore, fructose 1,6 biphosphatase, glucose-6-phosphatase, malondialdehyde (MDA) and proinflammatory cytokines levels were also ameliorated in the BRE-treated diabetic rats, while pancreatic antioxidant enzymes activities (GSH, SOD and CAT) were significantly increased in the treated rats. Conclusions: In conclusion, the results showed that BRE effectively displayed antidiabetic effects and has possible value for antidiabetic oral medication.

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A Novel Strategy for the Development of Functional Foods to Improve Energy Metabolism Disorders: Stable Isotope-Resolved Metabolomics

Meng

et al. 2023

Food Bioprocess Technol

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Watermelon (Citrullus lanatus) leaf extract attenuates biochemical and histological parameters in high‐fat diet/streptozotocin‐induced diabetic rats

Cited by 3 publications

References 42 publications

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

Therapeutic Efficacy of Polyphenol-Rich Fraction of Boesenbergia rotunda in Diabetic Rats: A Focus on Hypoglycemic, Antihyperlipidemic, Carbohydrate Metabolism, Antioxidant, Anti-Inflammatory and Pancreato-Protective Activities

A Novel Strategy for the Development of Functional Foods to Improve Energy Metabolism Disorders: Stable Isotope-Resolved Metabolomics

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