Sox15 Is Required for Skeletal Muscle Regeneration

Lee, Heon-Jin; Göring, Wolfgang; Ochs, Matthias; Mühlfeld, Christian; Steding, Gerd; Paprotta, Ilona; Engel, Wolfgang; Adham, Ibrahim M.

doi:10.1128/mcb.24.19.8428-8436.2004

Cited by 75 publications

(74 citation statements)

References 38 publications

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“…It has been reported that c-Met [89], M-cadherin [90], FoxK [91], Pax7 [15], NCAM [92], syndecan 3 and 4 [93], CD34 [94], caveolin-1 [95], Sox 8 [96], Sox 15 [97], VCAM-1 [98], integrin 7 [99], 1 integrin [100], calcitonin receptor (CTR) [101], lamin A/C [99], emerin [99], Hey1, and Heyl [102] are expressed by quiescent satellite cells, and their expression increases once satellite cells are activated and proliferated [86] (Figure 4). Pax3, the paralog of Pax7, is also expressed in quiescent muscle satellite cells in a subset of muscles.…”

Section: The Phase Of Regeneration Remodeling and Maturationmentioning

confidence: 99%

The Basis of Muscle Regeneration

Musarò

2014

Advances in Biology

107

138

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Muscle regeneration recapitulates many aspects of embryonic myogenesis and is an important homeostatic process of the adult skeletal muscle, which, after development, retains the capacity to regenerate in response to appropriate stimuli, activating the muscle compartment of stem cells, namely, satellite cells, as well as other precursor cells. Moreover, significant evidence suggests that while stem cells represent an important determinant for tissue regeneration, a "qualified" environment is necessary to guarantee and achieve functional results. It is therefore plausible that the loss of control over these cell fate decisions could lead to a pathological transdifferentiation, leading to pathologic defects in the regenerative process. This review provides an overview about the general aspects of muscle development and discusses the cellular and molecular aspects that characterize the five interrelated and time-dependent phases of muscle regeneration, namely, degeneration, inflammation, regeneration, remodeling, and maturation/functional repair.

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Section: The Phase Of Regeneration Remodeling and Maturationmentioning

confidence: 99%

The Basis of Muscle Regeneration

Musarò

2014

Advances in Biology

107

138

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“…Sox8 and Sox15 are expressed in the satellite cell population in adult skeletal muscle ( Fig. 4; Schmidt et al 2003;Lee et al 2004). Biochemical and overexpression studies suggest that these Sox factors inhibit myogenesis through the transcriptional repression of MyoD family members (Schmidt et al 2003).…”

Section: Nuclear Factorsmentioning

confidence: 99%

Muscle stem cells in development, regeneration, and disease

Shi¹,

Garry²

2006

Genes Dev.

432

394

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Somatic stem cell populations participate in the development and regeneration of their host tissues. Skeletal muscle is capable of complete regeneration due to stem cells that reside in skeletal muscle and nonmuscle stem cell populations. However, in severe myopathic diseases such as Duchenne Muscular Dystrophy, this regenerative capacity is exhausted. In the present review, studies will be examined that focus on the origin, gene expression, and coordinated regulation of stem cell populations to highlight the regenerative capacity of skeletal muscle and emphasize the challenges for this field. Intense interest has focused on cell-based therapies for chronic, debilitating myopathic diseases. Future studies that enhance our understanding of stem cell biology and repair mechanisms will provide a platform for therapeutic applications directed toward these chronic, life-threatening diseases.

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“…Thus Sox8 and Sox15 are expressed in muscle satellite cells and are down-regulated during myogenic differentiation (Schmidt et al 2003;Beranger et al 2000). Mice lacking Sox15 are viable but appear to have impaired skeletal muscle regeneration (Lee et al 2004). On the other hand, Sox6 has been shown to play a critical role in the fiber type differentiation of skeletal muscle both in both the mouse and fish.…”

mentioning

confidence: 99%

A Sox5 gene is expressed in the myogenic lineage during trout embryonic development

Rescan¹,

Rallière²

2010

Int. J. Dev. Biol.

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Sox proteins form a family of transcription factors characterized by the presence of a DNA-binding domain called the high-mobility-group domain (HMG). The presence of a large number of potential Sox5 binding sites in the trout promoter of Pax7, a gene which has emerged as an important regulator of neural and somite development, prompted us to clone trout Sox5 and to examine its expression pattern in the developing trout embryo. Using whole mount in situ hybridisation, we show here that the Sox5 transcript is first expressed before segmentation in the whole presomitic mesoderm. In newly formed somites, Sox5 labelling was observed in myogenic progenitor cells of the posterior and anterior walls. As the somite matured rostrocaudally, Sox5 expression disappeared from the differentiating embryonic myotome, deep in the somite, to become restricted to the undifferentiated myogenic precursors forming the dermomyotome-like epithelium at the surface of the embryonic myotome. Sox5 was also expressed in the developing nervous system and in pectoral fin buds. On the whole, this work suggests a hitherto unappreciated role for Sox5 in regulating myogenic cells destined to muscle formation and growth.

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Sox15 Is Required for Skeletal Muscle Regeneration

Cited by 75 publications

References 38 publications

The Basis of Muscle Regeneration

The Basis of Muscle Regeneration

Muscle stem cells in development, regeneration, and disease

A Sox5 gene is expressed in the myogenic lineage during trout embryonic development

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