Sources, Formation, Reactivity and Determination of Quinones in the Atmosphere

Sousa, Eliane Teixeira; Lopes, Wilson Araújo; Andrade, Jailson B. de

doi:10.5935/0100-4042.20160034

Cited by 10 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Few structural differences are observed in these compounds; the presence of an electron-donor group (methoxyl) in the structure of physcion worsens the capture efficiency of the studied reactive species in comparison with an electron-acceptor group (hydroxyl) in the meta position of the emodin structure. The quinone nucleus of the anthraquinones possesses recognized redox capacity, with intermediate formation of the semiquinone radical and subsequent stabilization in hydroquinone [ 46 – 48 ].…”

Section: Resultsmentioning

confidence: 99%

Emodin, Physcion, and Crude Extract ofRhamnus sphaerospermavar.pubescensInduce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines

Moreira

Sorbo

Souza

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

There have been few studies on the pharmacological properties of Rhamnus sphaerosperma var. pubescens, a native Brazilian species popularly known as “fruto-de-pombo.” The aim of this study was to investigate the scavenging capacity of emodin, physcion, and the ethanolic crude extract of Rhamnus sphaerosperma var. pubescens against reactive oxygen and nitrogen species, as well as their role and plausible mechanisms in prompting cell death and changes in AKT phosphorylation after cervical (SiHa and C33A) and oral (HSC-3) squamous cell carcinoma treatments. Emodin was shown to be the best scavenger of NO• and O2•−, while all samples were equally effective in HOCl/OCl− capture. Emodin, physcion, and the ethanolic extract all exhibited cytotoxic effects on SiHa, C33A, HSC-3, and HaCaT (immortalized human keratinocytes, nontumorigenic cell line), involving mixed cell death (apoptosis and necrosis) independent of the caspase activation pathway. Emodin, physcion, and the ethanolic extract increased intracellular oxidative stress and DNA damage. Emodin decreased the activation of AKT in all tumor cells, physcion in HSC-3 and HaCaT cells, and the ethanolic extract in C33A and HaCaT cells, respectively. The induction of cancer cell death by emodin, physcion, and the ethanolic crude extract of Rhamnus sphaerosperma var. pubescens was related to an increase in intracellular oxidative stress and DNA damage and a decrease in AKT activation. These molecules are therefore emerging as interesting candidates for further study as novel options to treat cervical and oral carcinomas.

show abstract

Section: Resultsmentioning

confidence: 99%

Emodin, Physcion, and Crude Extract ofRhamnus sphaerospermavar.pubescensInduce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines

Moreira

Sorbo

Souza

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Simultaneous quantifications of quinones in the gas and particle phases remain scarce, and therefore there is little information to date regarding their phase-distribution [21]. The equilibrium between the gas and particle phases is directly related to the vapor pressure of the quinones and varies from season to season [67]. Here, the vapor pressure criterion (p • L, Pa at 298 K) was used for quinones, which were separated as follows: 1 × 10 −1 (1,4-NQ); 1 × 10 −3 (9,10-PQ); 1 × 10 −4 (1,4-PQ, 1,4-AQ, 9,10-AQ); 1 × 10 −7 (1,2-BAQ, 5,12-NAQ) and 1 × 10 −8 (1,4-CQ).…”

Section: Gas-pm 1 Distributionmentioning

confidence: 99%

Atmospheric Distribution of PAHs and Quinones in the Gas and PM1 Phases in the Guadalajara Metropolitan Area, Mexico: Sources and Health Risk

et al. 2018

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) and quinones in the gas phase and as submicron particles raise concerns due to their potentially carcinogenic and mutagenic properties. The majority of existing studies have investigated the formation of quinones, but it is also important to consider both the primary and secondary sources to estimate their contributions. The objectives of this study were to characterize PAHs and quinones in the gas and particulate matter (PM 1 ) phases in order to identify phase distributions, sources, and cancer risk at two urban monitoring sites in the Guadalajara Metropolitan Area (GMA) in Mexico. The simultaneous gas and PM 1 phases samples were analyzed using a gas chromatography-mass spectrometer. The lifetime lung cancer risk (LCR) due to PAH exposure was calculated to be 1.7 × 10 −3 , higher than the recommended risk value of 10 −6 , indicating a potential health hazard. Correlations between parent PAHs, criteria pollutants, and meteorological parameters suggest that primary sources are the main contributors to the Σ 8 Quinones concentrations in PM 1 , while the secondary formation of 5,12-naphthacenequinone and 9,10-anthraquinone may contribute less to the observed concentration of quinones. Additionally, naphthalene, acenaphthene, fluorene, phenanthrene, and anthracene in PM 1 , suggest photochemical degradation into unidentified species. Further research is needed to determine how these compounds are formed.

show abstract

“…They are generally colored and semi-volatile, belonging to the class of polycyclic aromatic oxygenated hydrocarbons (HPAO). The structure of the quinones presents two carbonyl groups in an unsaturated ring of six carbon atoms, and they are classified as benzoquinones, naphthoquinones, anthraquinones or phenanthraquinones, according to the type of aromatic system (Sousa, Lopes, & Andrade, 2016).…”

Section: Discussionmentioning

confidence: 99%

Secondary metabolites produced by endophytic fungi: novel antifungal activity of fumiquinone B

Grigoletto¹,

Correia²,

Abraham³

et al. 2019

Acta Sci. Biol. Sci.

View full text Add to dashboard Cite

Fungi are present in the most diverse environments including the interior of plant tissues, living as endophytes without causing apparent damage. These endophytes are producers of secondary metabolites, also known as natural products, such as fungicides. Here, we evaluated the ethyl acetate fractions obtained from endophytic fungi isolated from plants in the genus Begonia. The fractions were submitted to inhibitory test against the plant pathogens Diaporthe phaseolorum and Colletotrichum gloeosporioides. From the 88 ethyl acetate fractions evaluated, 14.7 % inhibited C. gloeosporioides and 11.3 % inhibited D. phaseolorum. One fungal isolate displaying an active fraction was selected for chemical investigation. The fungus identified as Neopestalotiopsis sp., produced a compound that was active against D. phaseolorum, with a MIC of 312 µg mL-1 (1,695.3 µM). The compound was identified by mass spectrometry and 1H NMR as the known compound fumiquinone B. The results highlight that the endophytes are capable of producing compounds that may be used to control plant pathogens. The compound fumiquinone B is reported for the first time as an antifungal agent against D. phaseolorum, a relevant plant pathogen worldwide. This is also the first report of the production of fumiquinone B by the genus Neopestalotiopsis.

show abstract

Sources, Formation, Reactivity and Determination of Quinones in the Atmosphere

Cited by 10 publications

References 50 publications

Emodin, Physcion, and Crude Extract ofRhamnus sphaerospermavar.pubescensInduce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines

Emodin, Physcion, and Crude Extract ofRhamnus sphaerospermavar.pubescensInduce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines

Atmospheric Distribution of PAHs and Quinones in the Gas and PM1 Phases in the Guadalajara Metropolitan Area, Mexico: Sources and Health Risk

Secondary metabolites produced by endophytic fungi: novel antifungal activity of fumiquinone B

Contact Info

Product

Resources

About