Sorologia e histopatologia de Toxoplasma gondii e Neospora caninum em cães portadores de distúrbios neurológicos

Giraldi, Jamile Haddad; Bracarense, Ana Paula Frederico Rodrigues Loureiro; Vidotto, Odilon; Tudury, Eduardo Alberto; Navarro, Italmar Teodorico; Batista, Thiago Neves

doi:10.5433/1679-0359.2002v23n1p9

Cited by 12 publications

(14 citation statements)

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“…In the present study, occurrences of antibodies in dogs with neurological signs were greater for T. gondii (21.08%) than for N. caninum (11.56%), or for both parasites together (2.72%). Results like these were previously described by Mineo et al (2001), Giraldi et al (2002), Varandas et al (2001) and Klein and Müller (2001), among others. In Minas Gerais, the seroprevalences were 3.3, 3.7 and 3.1%, respectively, for T. gondii, N. caninum and both parasites together, in dogs with neurological, respiratory and/or gastrointestinal diseases (MINEO et al, 2001).…”

Section: Discussionsupporting

confidence: 89%

“…There are only a few reports on the seroprevalence of neosporosis and toxoplasmosis among dogs with neurological signs (VARANDAS et al, 2001;GIRALDI et al, 2002;YILDIZ et al, 2009). In the present study, occurrences of antibodies in dogs with neurological signs were greater for T. gondii (21.08%) than for N. caninum (11.56%), or for both parasites together (2.72%).…”

Section: Discussionmentioning

confidence: 99%

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Occurrence of antibodies against Neospora caninum and/or Toxoplasma gondii in dogs with neurological signs

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Montiani‐Ferreira

Richartz

et al. 2011

Rev. Bras. Parasitol. Vet.

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This study aimed to evaluate occurrences of antibodies against Neospora caninum and Toxoplasma gondii in dogs with neurological signs. Blood samples from 147 dogs were collected: 127 from owned dogs (attended at the Veterinary Teaching Hospital of the Federal University of Paraná (HV-UFPR) and at private veterinary clinics in the city of Curitiba), and 20 from stray dogs found in Curitiba's metropolitan region. The dogs presented one or more of the following neurological signs: seizures, paresis or paralysis, ataxia, behavioral abnormalities, sensory and somatic disorders and chorioretinitis. The samples were analyzed by means of the indirect fluorescent antibody test (IFAT), at a cutoff dilution of 1:50. Out of the 147 samples obtained, 17 (11.56%) were seropositive for N. caninum, 31 (21.08%) for T. gondii and four (2.72%) for both protozoa. Serum titration on the positive animals showed that 54.83% (17/31) and 41.18% (7/17) had titers > 1:200 against T. gondii and N. caninum, respectively. A significant difference in seropositivity for T. gondii (P = 0.021; OR = 2.87; CI = 1.1 > 2.8 > 7.4) was observed between owned dogs (18.11%) and stray dogs (40%). Inclusion of serological tests for neosporosis and toxoplasmosis is recommended in diagnosing neurological diseases in dogs.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Occurrence of antibodies against Neospora caninum and/or Toxoplasma gondii in dogs with neurological signs

Plugge

Montiani‐Ferreira

Richartz

et al. 2011

Rev. Bras. Parasitol. Vet.

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“…Os sinais de febre, perda de peso, sinais neurológicos, alterações eritrocitárias (anemia), leucocitárias (linfopenia) e plaquetárias (trombocitopenia moderada) encontradas no paciente com título de infecção aguda do presente trabalho, vêm de encontro com o conceito de acometimento multissistêmico na infecção pelo T. gondii. Existe a possibilidade de co-infecções com outros agentes como Ehrlichia canis (Girardi et al 2014) e vírus da cinomose canina (CDV) (Aguiar et al 2012); nessas situações mais de um agente poderia estar contribuindo com os sinais clínicos neurológicos/não-neurológicos, assim como as alterações laboratoriais (Giraldi et al 2002). No entanto, a possibilidade de co-infecção com E. canis e/ ou CDV não foi avaliada nesse estudo.…”

Section: Resultsunclassified

Estudo epidemiológico e avaliação de fatores de risco da infecção por Toxoplasma gondii e achados clinico-patológicos da infecção aguda em cães admitidos em um Hospital Escola Veterinário

et al. 2016

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RESUMO.-Esse trabalho teve como objetivo estudar a prevalência e respectivos fatores de risco para infecção do Toxoplasma gondii em cães provenientes de uma população We aimed to verify the prevalence and risk factors for Toxoplasma gondii infection in dogs addimitted at the hospital. We also assessed the occurrence rates and the clinical and pathological repercussion of the acute infection by T. gondii in these animals. Antibodies were detected in 7% (26/386) of a population of 386 dogs of both genders and different breeds and ages. Only variables, eating offal, rural origin and contact with cattle have significant values of p<0.05. Dogs from rural areas showed higher risk (OD=7.00) of infection than those of urban origin. In 6.5% (25/386) contact titles were detected (between 16 and 256); these titles do not necessarily mean acute infection, but only prior exposure. The recognition of prior infection by T. gondii is vital in those hospital patients. Depending on the cause of admission, although not being toxoplasmosis the responsible, the patient should receive prophylactic anti-parasite treatment or be monitored for further treatment in case of further acute occurrence of the disease by recrudescence of encysted bradyzoites. Only one dog (3:44%, 1/386) was admitted with high titer, what may be suggestive of acute infection (title of 4096). Although the dog with acute infection has shown neurological signs, caution is required not to extrapolate a false interpretation that toxoplasmosis is the main responsible for neurological signs, since numerous other cases included in this study had neurological signs without title of acute infection, even title of prior contact. Acute toxoplasmosis was not a significant clinic disease in this hospital; however differential diagnosis should be made in ill patients, especially those from rural areas, and definitive diagnosis must be reached for the correct therapeutic approach.

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“…Similarly, it is widely known that severe clinical manifestation of toxoplasmosis occurs in immunosuppressed dogs (MORETTI et al, 2002). Additionally, there are reported cases of dogs with neurological disorders and the presence of T. gondii cysts in which lesions consistent with distemper were absent (GIRALDI et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Clinical, pathological, and immunohistochemistry characterization of toxoplasmosis in dogs with distemper in the semiarid region of Paraíba, Brazil

Frade

Maia

Andrade

et al. 2015

SCA

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The objective of this study was to describe the clinical, pathological, and immunohistochemistry characteristics of five cases of toxoplasmosis, an infection often associated with distemper in dogs. From January 2000 to December 2012, a retrospective study was performed analyzed dogs with distemper in the semiarid region of Paraíba. We evaluated this sample to focus on individuals who presented with concomitant structures in protozoa characteristics, and performed immunohistochemistry (IHC) tests using polyclonal anti-Toxoplasma gondii antibody. In all cases, the clinical signs were similar including digestive changes, as well as respiratory, neurological, and ocular lesions, suggesting an infection of canine distemper virus. The diagnosis of distemper was confirmed on histopathological analysis depending on the presence of intranuclear and intracytoplasmic eosinophilic inclusion bodies in different tissues. Histopathological examination also revealed the characteristic presence of parasitic cysts T. gondii in the brain in four cases, and in the lung in one case. The brain cysts were associated with multifocal areas of malacia and lung there was alveolar septa thickening due to infiltration of macrophages, lymphocytes, and plasma cells, with moderate proliferation of type II pneumocytes and coalescing multifocal areas of necrosis. These cysts are characterized by round and strongly basophilic structures, measuring approximately 5 to 70 µm, delimited by thin wall, stained by hematoxylin and eosin, and immunomarked as brown by immunohistochemistry (IHC) using the chromogen DAB. The diagnosis of toxoplasmosis associated with infection by canine distemper virus in the five case studied was based on microscopic findings and confirmed by immunohistochemistry. Toxoplasmosis should be included in the differential diagnosis of dogs with severe progressive systemic signs, especially when respiratory and neurological involvement is suspected. ResumoObjetivou-se com este trabalho descrever as características clínicas, patológicas e imuno-histoquímica de cinco casos de toxoplasmose associados à cinomose em cães no semiárido da Paraíba. Para isso, foi realizado um estudo retrospectivo durante o período de janeiro de 2000 a dezembro de 2012, sendo identificados e selecionados os casos de cães com cinomose. Destes, foram avaliados os que apresentavam concomitantemente estruturas características de protozoários e realizada a imunohistoquímica (IHQ) com anticorpo policlonal anti-Toxoplasma gondii. Em todos os casos os sinais clínicos foram semelhantes e sugestivos de infecção pelo vírus da cinomose canina, variando de alterações digestivas, respiratórias, neurológicas e lesões oculares. O diagnóstico de cinomose foi confirmado na histopatologia através da presença de corpúsculos de inclusões virais eosinofílicos intranucleares e intracitoplasmáticos em diferentes tecidos. O exame histopatológico revelou ainda a presença dos cistos parasitários característicos de T. gondii no encéfalo em quatro casos e no pulmão em um cas...

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Sorologia e histopatologia de Toxoplasma gondii e Neospora caninum em cães portadores de distúrbios neurológicos

Cited by 12 publications

References 6 publications

Occurrence of antibodies against Neospora caninum and/or Toxoplasma gondii in dogs with neurological signs

Occurrence of antibodies against Neospora caninum and/or Toxoplasma gondii in dogs with neurological signs

Estudo epidemiológico e avaliação de fatores de risco da infecção por Toxoplasma gondii e achados clinico-patológicos da infecção aguda em cães admitidos em um Hospital Escola Veterinário

Clinical, pathological, and immunohistochemistry characterization of toxoplasmosis in dogs with distemper in the semiarid region of Paraíba, Brazil

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