Sorafenib response in hepatocellular carcinoma: MicroRNAs as tuning forks

Kanthaje, Shruthi; Makol, Ankita; Chakraborti, Anuradha

doi:10.1111/hepr.12991

Cited by 26 publications

(15 citation statements)

References 76 publications

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“…However, the absence of obvious early symptoms results in most HCC cases being first diagnosed at advanced stage. The principal therapeutic agent for advanced HCC, sorafenib, is greatly limited by its drug-resistance [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Non-coding RNA in drug resistance of hepatocellular carcinoma

Ding

Lou

et al. 2018

Bioscience Reports

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Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment, and prognosis of HCC. In this review, we first overviewed up-to-date findings regarding miRNA and lncRNA in drug resistance of HCC, then summarized specific mechanisms that they modulate chemoresistance of HCC, and finally discussed their potential clinical application in overcoming the obstacle of HCC chemoresistance in the future.

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Section: Introductionmentioning

confidence: 99%

Non-coding RNA in drug resistance of hepatocellular carcinoma

Ding

Lou

et al. 2018

Bioscience Reports

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“…Hepatocellular cancer (HCC) is the major liver malignancy that attributes toward the second foremost cause of cancer-related mortality worldwide [1]. Individual hereditary and environmental factors proved to be associated with the incidence of HCC [2].…”

Section: Introductionmentioning

confidence: 99%

The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis

et al. 2018

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Hepatocellular cancer (HCC) is one of the major causes of cancer-related mortality. Genetic polymorphisms may affect the susceptibility and clinical outcomes of cancers. We aim to manifest the association of single nucleotide polymorphisms (SNPs) of lncRNA-H19 gene with the risk and prognosis of HCC. A total of 944 samples composed of 472 HCC patients and 472 matched controls were included in the risk analysis and amongst them 350 HCC samples were investigated in the prognosis analysis. KASP method was conducted for the SNP genotyping. The TT + CT genotype of rs2839698 was found to be associated with a 1.32-fold increased HCC risk (P=0.037, 95% confidence interval (CI) = 1.02–1.70). In the stratified analysis, rs2839698 (odds ratio (OR) = 1.57, P=0.007, 95% CI = 1.13–2.18) and rs3024270 (OR = 1.71, P=0.019, 95% CI = 1.09–2.68) were found to show more obvious increased HCC risk in the age ≤60 subgroup. And we found that rs2839698 showed an increased HCC risk in the ever smoking subgroup. But in the male subgroup of rs2735971, it showed a decreased HCC risk. Furthermore, haplotype analysis showed that rs2735971-rs2839698-rs3024270 G-T-C significantly increased the risk of HCC (OR = 1.23, 95% CI = 1.01–1.51, P=0.043). Multilogistic analysis revealed no significant results of the interaction effects of the SNPs and environment factors. And in our study, rs2839698 showed a significant poor prognosis in the ever smoking subgroup (hazard rate (HR) = 5.19, 95% CI = 1.12–24.07, P=0.035). lncRNA-H19 rs2839698 SNP has the potential to be predictors for HCC risk and prognosis.

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“…MicroRNA (miRNA or miR) is a class of endogenous, highly conserved non-coding RNA molecules 18–22 nucleotides in length (22). miRNAs inhibit the translation of proteins by binding to the 3′-untranslated region (UTR) of mRNAs (23). miRNAs are stable in body fluids, making them suitable biomarkers for diseases (24).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN

Kong

2018

Exp Ther Med

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The aim of the present study was to investigate the role of microRNA (miR)-494-3p in myocardial injury in patients with septic shock and the underlying mechanism. A total of 22 patients with sepsis and 17 patients with septic shock were included in the present study. In addition, 20 healthy subjects were recruited as the control group. Peripheral blood was collected from all subjects and a rat cardiomyocyte model of myocardial injury was constructed. Reverse transcription-quantitative polymerase chain reaction was used to measure miR-494-3p expression, while cell counting kit-8 assays were performed to assess cell proliferation. Flow cytometry was performed to investigate cell cycle distribution and apoptosis. Lactate dehydrogenase (LDH) assays were performed to measure LDH levels. ELISA was also performed to measure LDH, tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels in cell culture supernatants. Western blotting was employed to detect phosphatase and tensin homolog (PTEN) protein expression and dual luciferase reporter assays were performed to identify the interaction between miR-494-3p and PTEN mRNA. Reduced miR-494-3p expression was correlated with myocardial damage in patients with septic shock. Sera from patients with septic shock downregulated miR-494-3p expression in rat cardiomyocytes. miR-494-3p overexpression inhibited rat cardiomyocyte injury induced by treatment with sera from patients with septic shock. Furthermore, miR-494-3p overexpression reduced the synthesis and release of TNF-α and IL-6 from rat cardiomyocytes. PTEN knockdown alleviated rat cardiomyocyte injury following treatment with serum from patients with septic shock. PTEN was demonstrated to induce the release of TNF-α and IL-6 from rat cardiomyocytes treated with septic shock serum, while miR-494-3p was demonstrated to bind to the 3′-untranslated seed region of PTEN mRNA to regulate its expression. The results of the present study suggest that miR-494-3p is downregulated in the peripheral blood of patients with septic shock and is negatively correlated with myocardial injury. The present study also indicates that miR-494-3p regulates PTEN expression, inhibits sepsis-induced myocardial injury and protects the function of cardiomyocytes. The protective effect and mechanism of action of miR-494-3p indicate that it has potential for use in the clinical diagnosis and therapy of myocardial damage.

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Sorafenib response in hepatocellular carcinoma: MicroRNAs as tuning forks

Cited by 26 publications

References 76 publications

Non-coding RNA in drug resistance of hepatocellular carcinoma

Non-coding RNA in drug resistance of hepatocellular carcinoma

The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis

MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN

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