Non-coding RNA in drug resistance of hepatocellular carcinoma

Ding, Bo; Lou, Weiyang; Xu, Liang; Fan, Weimin

doi:10.1042/bsr20180915

Cited by 90 publications

(72 citation statements)

References 86 publications

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“…As flexible scaffolds, lncRNAs can also absorb different macromolecules, form complexes, and play different biological functions. Many recent reports have revealed that lncRNAs are involved in the multiple biological functions of tumor cells, such as proliferation, invasion, metastasis, and drug resistance [11][12][13][14][15].…”

Section: Lncrnas As Novel Regulators In Hcc Metastasismentioning

confidence: 99%

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

et al. 2019

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Long non-coding RNAs (lncRNAs) play multifaceted roles in modulating gene expression under both physiological and pathological processes. The dysregulation of lncRNAs has been increasingly linked with many human diseases, including a plethora of cancers. Mounting evidence indicates that lncRNAs are aberrantly expressed in hepatocellular carcinoma (HCC) and can regulate HCC progression, as well as metastasis. In this review, we summarize the recent findings on the expanding roles of lncRNAs in modulating various functions of HCC, and elaborate on how can lncRNAs impact HCC metastasis and progression via interacting with chromatin, RNA, and proteins at the epigenetic, transcriptional, and post-transcriptional levels. This mini-review also highlights the current advances regarding the signaling pathways of lncRNAs in HCC metastasis and sheds light on the possible application of lncRNAs for the prevention and treatment of HCC.

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Section: Lncrnas As Novel Regulators In Hcc Metastasismentioning

confidence: 99%

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

et al. 2019

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“…11 CircRNAs may also play a key role in the development of drug resistance. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of cancer, such as HCC, 142,249 lung cancer, 250,251 gastric cancer, 252,253 breast cancer, 254,255 multiple myeloma, 256 acute myeloid leukemia, 234 prostate cancer, 257 bladder cancer, 258 among others. The up-to-date information regarding the role of circRNAs in the resistance of tumors to chemotherapy has been recently summarized with multiple mechanisms, such as modulating various regulatory pathways and processes including the ceRNA regulatory network axis, EMT process, regulation of ABC transporters, apoptosis, autophagy, and CSCs, among others although many physiological processes and biological signaling pathways through which circRNAs are involved in drug resistance still remained unknown.…”

Section: Discussion and Prospectivementioning

confidence: 99%

“…137 Overall, circRNAs played key roles in tumorigenesis and development, epigenetic regulation, drug resistance, and could be considered as immune-associated biomarker and therapeutic target in HCC. [138][139][140][141][142][143][144] Regardless, more in-depth study of circRNA biofunctions in HCC is greatly desired.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Tang

Hann

2020

OTT

136

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Circular RNA (circRNA) is an intriguing class of RNA with covalently closedloop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.

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“…A number of research teams have demonstrated the involvement of lncRNAs in chemoresistance and chemosensitivity of different types of cancer [222][223][224][225][226][227]. In osteosarcoma, chemotherapy plays an important role, but its efficacy is limited by acquired resistance to different chemotherapeutic drugs, mainly cisplatin and doxorubicin [228].…”

Section: Lncrnas As Predictive Biomarkers and Drug Resistance In Ostementioning

confidence: 99%

Long Noncoding RNAs in Osteosarcoma: Mechanisms and Potential Clinical Implications

Valavanis¹,

Stanc²

2019

Osteosarcoma – Diagnosis, Mechanisms, and Translational Developments

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Long noncoding RNAs (lncRNAs) are noncoding transcripts consisting of a diverse class of long RNAs of more than 200 nucleotides in length. Recent studies have shown that lncRNAs are involved in cell signal transduction pathways, cell cycle and cell death regulation, chromatin remodeling, and gene expression regulation at the transcriptional and posttranscriptional levels. They are also involved in the metastatic process of different types of tumors, such as urothelial carcinoma, colon carcinoma, breast carcinoma, lung carcinoma, and hepatocellular carcinoma. In addition, lncRNAs demonstrate precise expression patterns in specific tissues and cells and therefore play important roles in cell differentiation and tissue development. In this chapter, we review the molecular mechanisms of lncRNA cell functions and their involvement in the pathogenesis, progression, and metastasis of osteosarcoma, a rare bone tumor of childhood and adolescence. We also review emerging clinical implications of lncRNA use as potential prognostic biomarkers and therapeutic targets, as well as their putative involvement in drug resistance, in osteosarcoma progression, and in therapeutic interventions.

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Non-coding RNA in drug resistance of hepatocellular carcinoma

Cited by 90 publications

References 86 publications

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Long Noncoding RNAs in Osteosarcoma: Mechanisms and Potential Clinical Implications

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