Sonodynamic excitation of nanomicelle curcumin for eradication of Streptococcus mutans under sonodynamic antimicrobial chemotherapy: Enhanced anti-caries activity of nanomicelle curcumin

Sonodynamic antimicrobial chemotherapy: An emerging alternative strategy for microbial inactivation

“… 42 kHz, 0.30 W/cm 2 , 15 min. C. albicans In vitro 90%~100% [13] MLP18 20 μM 1.0 MHz, 0.97 W/cm 2 , 5 min E. coli MRSA In vivo (mice) ~60% ~80% [1] CNPs-ICG 1000 μg/mL 1 MHz, 1.56 W/cm 2 , 1 min Biofilm ( P. gingivalis, Prevotella intermedia ) In vitro 57.9% [61] Gentamicin (Nano-sized liposomes) 0.8 mg/mL 2.25 MHz, 4.4 W/cm 2 Ralstonia insidiosa biofilm In vitro 73% [87] Pd@Pt-T790 25 ppm 50 ppm 1.0 MHz, 0.97 W/cm 2 , 50% cycle, 8 min MRSA In vitro In vivo (mice) 1 ~ 5 >6 [73] Fe@UCNP-HMME 4.75 µg 1 W/cm 2 , 10 min 2 W/cm 2 , 10 min E. coli MRSA In vitro 60% 70% [22] UCNP@SiO 2 -RB 125 μg/mL 2 W/cm 2 , 10 min E. coli MRSA In vitro 70% 70% [23] UCNP@mSiO 2 (RB)-AgNPs 45 µg/mL 2 W/cm 2 , 10 min MRSA In vitro 5 [88] NM@Cur 50 mM 1.56 W/cm 2 , 1 min S. mutans In vitro 99.9% (~6 log) [75] Xanthene dye ...…”

“…To end these problems, a promising way is the chemical conjugation of the sonosensitizers onto the surface of nanoparticles or inside the mesoporous nanoparticles. A similar approach was adopted by Pourhajibagher et al [75] . The researchers used PEG-PE backbone to bridge with curcumin forming an NM@Cur, which significantly enhanced the aqueous solubility, stability and dissolution of the poorly water-soluble curcumin.…”

“…For example, nanomicelle curcumin (NM@Cur) is prepared by chemically combining curcumin with polyethylene glycol- L -α phosphatidyl ethanolamine (PEG-PE) backbone. The NM@Cur was used by Pourhajibagher et al [75] as sonosensitizer for the eradication of S. mutans under SACT. The findings showed that when treated by NM@Cur-mediated SACT, the number of S. mutans was decreased by 99.9%, while Cur-mediated SACT reduced only 90.8% of the viable counts.…”

The promise of low-intensity ultrasound: A review on sonosensitizers and sonocatalysts by ultrasonic activation for bacterial killing

“… Sonosensitizers Purpose Mechanisms Ref. HMME Medical Increase in intracellular ROS [52] PPPC Medical Cell membrane damage [53] Fe@UCNP- HMME Medical Cell membrane damage [65] UCNP@SiO 2 -RB/HMME Medical Cell membrane damage [76] Pd @ Pt-T790 Medical Increase in intracellular ROS [29] Cur Food DNA damage a [61] Cur Medical DNA damage a [60] Cur Medical Downregulation in virulence genes [68] Cur Medical Cell membrane damage [67] Hypocrellin B Medical Cell membrane damage DNA damage a [62] Nano-emodin Medical Downregulation in virulence genes [63] Propyl gallate Food Lipid peroxidation [69] Amphotericin B Medical Increase in intracellular ROS [70] MLP18 Medical Cell membrane damage Increase in intracellular ROS Drug delivery [38] TiO 2 Medical Oxidative stress response [71] Non-woven TiO 2 Environment Lipid peroxidation …”

Anticancer and Antibacterial Effect of Eucalyptus Camaldulensis, in Vitro

“…To assess the effects of this drug, viability tests are usually used. To evaluate the toxicity and liver enzymes, such as ASL, ALT and ALP, cell culture is normally used(5, [15][16][17]. The current study aimed to evaluate the effects of E. camaldulensis hydroalcoholic extract on the human lung cancer cell line and analyze its antibacterial and antiviral properties.…”