Sonodynamic antimicrobial chemotherapy: An emerging alternative strategy for microbial inactivation

Abstract

Highlights Fundamental mechanisms of SACT have yet to be well clarified. SACT is effective on bacteria and biofilms. SACT has foreseeable medical and environmental applications. Further understanding of SACT is needed to progress the field.

Contribution of antimicrobial photo-sonodynamic therapy in wound healing: an in vivo effect of curcumin-nisin-based poly (L-lactic acid) nanoparticle on Acinetobacter baumannii biofilms

“…aSDT is analogous to aPDT except that drug activation is obtained via ultrasound instead of light [ 17 ]. Similar to aPDT, aSDT process generates ROS through the ultrasound-mediated stimulated sonosensitizer in the presence of O 2 and the ultrasound-activated cavitation effects can destruct the microbial cells [ 15 , 17 ]. Following the development of the biological activity of aPDT and aSDT in recent years, many sensitizers were found to have both photodynamic and sonodynamic antimicrobial effects.…”

“…Recently, the photo-sono-biological and photo-sono-killing potential of Cur has been explored due to its capability of producing ROS, a free radical, and can play a role in intracellular compounds, activating transcription factors, and altering cytokines [ 15 – 19 ]. In this study, poly (L-lactic acid) as a nanocarrier was used to overcome the poor bioavailability of Cur-Nis.…”

“…Studies also showed that Cur has significant antimicrobial effects at very low molarity following activation by light and/or ultrasound in the process of antimicrobial photodynamic therapy (aPDT) and antimicrobial sonodynamic therapy (aSDT) [ 13 , 15 – 19 ]. aPDT is a potential alternative approach, which is the photoinactivation of microorganisms and thereby kill cells by reactive oxygen species (ROS) generated by a harmless visible light-activated nontoxic photosensitizer in the presence of oxygen.…”

Combined use of ultrasound-assisted washing with in-package atmospheric cold plasma processing as a novel non-thermal hurdle technology for ready-to-eat blueberry disinfection

“…US can induce the generation of cavitation bubbles, and the collapsing bubbles can generate shear force and instantaneous high pressure, which can lead to sonoporation of the bacterial membrane [7] , [43] . The antibacterial effect of PAA and FC results in cell membrane damage via oxidation along with intracellular damage including enzyme inactivation and DNA damage [5] , [33] , [44] .…”

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

“…Sonodynamic therapy (SDT) is an innovative combination of PDT and ultrasound that involves exposing diseased tissues to chemical compounds that produce reactive oxygen species upon sensitization by means of low-intensity ultrasound. In addition to the reported anticancer research applications [ 146 ], it has been applied to antimicrobial research studies with promising results in vitro [ 147 , 148 , 149 ]. The evaluation of SDT may be illustrated with the comparison between PDT and SDT for Staphylococcus aureus biofilm samples [ 150 ].…”