“…Therefore sonochemistry [13] offers an alternative synthetic pathway for conversion of RNA molecules, without chemical structure modification, into a dense RNA nanoparticles. The sonochemicallyinduced assembly of nanoparticles [14][15][16] from siRNA involves cooperative interaction of individual RNA molecules that assemble in a predefined manner to form a larger three-dimensional structure, which size and composition are precisely controlled. Moreover, the sonochemical siRNA nanoparticulation stabilize siRNA molecules.…”