A series of novel 3-methyl-7-substituted-4H-1,4-benzothiazine-2-carbohydrazide (3a-e) and corresponding thiosemicarbazides (4-a-q); 2-[3-methyl-7-substituted-4H -1, 4-benzothiazine-2-yl]-N-(aryl) hydrazine carbothiamide have been synthesized. The thiosemicarbazide when cyclized with iodine via intramolecular cyclisation gave benzothiazonyl oxadiazoles (5-a-q); 5-(3-methyl -7-substitued-4H-1,4-benzothiazin-2-yl)-N -aryl-1,3,4-oxadiazol -2-amine and the compounds were tested for antibacterial and antifungal activities against different microorganisms.
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