Diabetes Mellitus isone of the most common diseases, especially in developing countries. Different tests are used for diagnosis and monitoring hyperglycemia, but these tests are not equal in the inadequacy. To detect the most accurate test for Diabetes mellitus diagnosis andmonitor.Three tests were used: urine sugar test, serum test, and blood test check. These tests were applied on 230 patients in Thi-Qar province. Information was taken from these patients to detect the relation between Diabetes mellitus and some factors like sex and psychological stress. As a result, the most accurate tests for Diabetes mellitus diagnosis and monitor are serum test and blood test check. The highest percent of diabetes disease in Thi-Qar province is related to genetics.