Sonoactivated Chemodynamic Therapy: A Robust ROS Generation Nanotheranostic Eradicates Multidrug‐Resistant Bacterial Infection

Abstract

Although ultrasound-based therapeutic strategies have achieved great success in the battle against antibiotic-resistant bacterial infections, various sonodynamic treatments still suffer from poor therapeutic efficiency, failing to completely eradicate infections. Thus, more potent strategies are urgently required. Herein, a novel ultrasound-driven treatment modality, sonoactivated chemodynamic therapy (SCDT), is proposed, which shows a robust generation of superoxide anion and destructive hydroxyl radical via sonotriggered catalytic reactions. This SCDT platform is prepared by grafting Fe 3+ onto polyethylenimine-modified bismuth oxybromide (BiOBr) nanoplates. During sonocatalysis, the introduction of Fe 3+ can effectively separate the holes (h +) and electrons (e-) of BiOBr NPs and shorten their transport path of valence electrons, resulting in the activation of multioxygen reduction and Fenton reaction to generate abundant reactive oxygen species against methicillin-resistant Staphylococcus aureus (MRSA) infection. More importantly, Fe 3+ can also serve as a magnetic resonance imaging (MRI) contrast agent to achieve the accurate diagnosis of bacterial infection. The SCDT-mediated bactericidal outcome can be monitored by in situ monitoring through MRI technique, revealing a complete elimination of MRSA myositis in mice. Collectively, its deep tissue penetration, high therapeutic efficacy, and noninvasive properties make SCDT a promising therapeutic modality for combating multidrug-resistant bacterial infection.

Reactive Oxygen Species-Related Ceftazidime Resistance Is Caused by the Pyruvate Cycle Perturbation and Reverted by Fe3 + in Edwardsiella tarda

“…A line of evidence has indicated that Fe 3+ reduces ROS via the Fenton system ( Song et al, 2020 ). However, information regarding whether Fe 3+ regulates ROS by other ways is absent in bacteria.…”

“…In the antibiotic-mediated killing mechanisms, antibiotics belonging to different classes activate the TCA cycle, supporting the formation of ROS (superoxide and hydrogen peroxide) via hyperactivation of the electron transport chain ( Dwyer et al, 2009 ; Van Acker and Coenye, 2017 ). Fe 3+ causes the activation of the Fenton reaction to generate abundant ROS against methicillin−resistant Staphylococcus aureus (MRSA) infection ( Song et al, 2020 ). Our recent publications have showed that the ROS induced by exogenous metabolites elevate aminoglycoside-mediated killing efficacy to EIB202 and Vibrio alginolyticus ( Ye et al, 2018 ; Zhang et al, 2020 ).…”

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

“…Similarly, Liu and co‐workers successfully fabricated Fe‐BBP NPs composed with Fe 3+ and polyethylenimine‐modified bismuth oxybromide (BiOBr) nanoplates for sonoactivated CDT (SCDT) against multidrug‐resistant bacterial infections. [ 85 ] The grafted Fe 3+ as shallow traps improved their sonocatalytic activity for enhanced ROS generation of SDT, and as catalyst activated Fenton reaction for CDT. The in vivo results demonstrated the effectiveness of Fe‐BBP NPs in diffuse lesions clearance in the infected site by the SDT and PDT.…”

Pathogenic Virus Detection by Optical Nanobiosensors

“…Recently, two-dimensional (2D) materials have received widespread attention due to their advantages of large surface area, good metallic conductivity, excellent biocompatibility, and characteristic absorption peaks, making them desirable for various biological applications. 79 , 80 , 81 On the other hand, dye-labeled single-stranded DNA (ssDNA) probes with high sensitivity and selectivity are usually used for the detection of target DNA or RNA, which mainly rely on the LRET via forming a fluorophore-quencher pair. Based on the excellent fluorescence-quenching ability and different affinity toward ssDNA versus dsDNA, Zhu et al.…”