Some properties of mammalian skeletal muscle fibres with particular reference to fibrillation potentials

Li, Choh-Luh; Shy, G. Milton; Wells, Jay

doi:10.1113/jphysiol.1957.sp005727

Cited by 70 publications

(22 citation statements)

References 21 publications

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“…No spontaneous action potential firing, similar to that recorded in de-nervated muscle (Li, Shy & Wells, 1957) In 18-to 26-day regenerates, e.p.p.s were evoked at most junctions at which m.e.p.p.s were observed, and these were also generally subthreshold for initiation of an action potential (Text- fig. 3).…”

Section: The Formation Of Synapses During Muscle Regenerationsupporting

confidence: 58%

The formation of synapses in regenerating mammalian striated muscle

Bennett¹,

Florin²,

Woog³

1974

The Journal of Physiology

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SUMMARY1. A histological and electrophysiological study has been made of the formation of synapses in soleus and extensor digitorum longus muscles of adult rats regenerating from minced muscle fragments.2. In the first 8 days of regeneration, myoblast and myotubes formed within the basement membranes of degenerating myofibres.3. Eleven-to fourteen-day regenerates contained fasicles of myotubes and myofibres and both nerves and spontaneous miniature end-plate potentials (m.e.p.p.s) were observed for the first time, although very few synapses show evoked end-plate potentials (e.p.p.s).4. Eighteen-to twenty-six-day regenerates contained myofibres on which only a single end-plate could be detected; 30 % of these synapses had a normal amplitude-frequency distribution of m.e

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Section: The Formation Of Synapses During Muscle Regenerationsupporting

confidence: 58%

The formation of synapses in regenerating mammalian striated muscle

Bennett¹,

Florin²,

Woog³

1974

The Journal of Physiology

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“…Action potentials were followed by a prolonged after-hyperpolarization, as seen in other skeletal muscle cultures (24,26) and in denervated muscle fibers (27). Spontaneously occurring subthreshold potentials and rhythmic spikes (26,28) similar to the fibrillation seen in denervated muscle fibers (28)(29)(30) were routinely recorded in many myotubes.…”

Section: And 10)mentioning

confidence: 57%

Formation of cholinergic synapses between dissociated sympathetic neurons and skeletal myotubes of the rat in cell culture.

Nurse¹,

O'Lague²

1975

Proc. Natl. Acad. Sci. U.S.A.

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Sympathetic principal neurons, dissociated from superior cervical ganglia of newborn rats, were plated into cultures containing rat skeletal myotubes formed from previously plated primary myoblasts. Electrophysiological evidence is presented that the neurons developed cholinergic synapses with the myotubes. In addition, the neurons developed cholinergic synapses with each other as previously reported [O'Lague et al. (1974) Proc. Nat. Acad. Sci. USA 71, 3602-36061. The

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“…Schwann cells were never seen in contact with denervated synaptic folds (n = 14) although none of the muscles were examined at times shorter than 5 weeks after denervation, a considerable time after the Schwann cells have previously been reported to migrate from above the folds in mammals (Bauer, Blumberg & Zacks, 1962;Nickel & Waser, 1968;Miledi & Slater, 1968;LUillman-Rauch, 1971 (Li, Shy & Wells, 1957;Thesleff, 1963). Bursts of action potential firing sometimes occurred coincident with insertion of the micro-electrode, but more frequently action potentials were generated at regular intervals (frequency range 05-20 Hz in different cells), the activity resembling that recorded from pace-maker tissue in the heart (Weidmann, 1956).…”

Section: Resultsmentioning

confidence: 98%

The formation of synapses in reinnervated mammalian striated muscle

Bennett¹,

McLachlan²,

Taylor³

1973

The Journal of Physiology

118

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SUMMARY1. The hemidiaphragm of the adult rabbit has a single band of endplates running around the middle of the muscle. A study has been made of the formation of synapses during spontaneous reinnervation of this muscle, using histological, ultrastructural and electrophysiological techniques.2. Following spontaneous reinnervation, silver-stained nerve terminals were found in association with cholinesterase-stained end-plates only in the region of the muscle corresponding to the original innervation band. 3. The regenerated nerve terminals were observed with the electronmicroscope in positions overlying or adjacent to the old synaptic folds.4. Spontaneous miniature end-plate potentials and evoked synaptic potentials were recorded only in the middle of the muscle fibres after remnervation. 5. The growth of the regenerating axons was not oriented towards the end-plate zone but followed muscle fibres and blood vessels in random directions.6. It is concluded that, in adult mammalian striated muscle, the old end-plate region is preferentially reinnervated as a consequence of some special property of the muscle fibre at this site.

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Some properties of mammalian skeletal muscle fibres with particular reference to fibrillation potentials

Cited by 70 publications

References 21 publications

The formation of synapses in regenerating mammalian striated muscle

The formation of synapses in regenerating mammalian striated muscle

Formation of cholinergic synapses between dissociated sympathetic neurons and skeletal myotubes of the rat in cell culture.

The formation of synapses in reinnervated mammalian striated muscle

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