Some Immunological Factors in Small Intestine Disease

Idelman, S

doi:10.1093/ajcn/21.9.1110

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…These immune cells found throughout the intestinal lamina propria aid in maintaining the homeostasis and integrity of the mucosa. The relationship between immunologic function and intestinal tissue integrity is critical for inhibiting enteric pathogenesis and dysfunction that may precipitate disease states [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of intestinal survival surgery on systemic and mucosal immune responses in SIV‐infected rhesus macaques

Edghill-Smith

Aldrich

Zhao

et al. 2002

J of Medical Primatology

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Evaluation of cellular immunity in the intestinal lamina propria of rhesus macaques has been used previously to assess protective immunity against mucosal simian immunodeficiency virus (SIV) challenges. As this technique requires survival surgery to obtain jejunal tissue, effects of surgical stress on the immune system were investigated. SIV-specific immune responses, including IgG and IgA binding antibodies in sera and mucosal secretions, IgG and IgA secreting cells in peripheral blood, IgG neutralizing antibodies, T-cell proliferative responses, and interferon-gamma secretion by peripheral blood mononuclear cells, were evaluated pre- and post-surgery in macaques immunized with adenovirus-SIV recombinant vaccines and SIV envelope protein and in SIV-infected macaques. No differences in these immune parameters were observed in SIV-naïve, immunized macaques or healthy SIV-infected macaques with regard to surgery. A dramatic increase in total IgA antibody level following surgery in the rectal secretions of one SIV-infected macaque that was rapidly progressing to AIDS and failed to recover from surgery was attributed to an abscess that developed at the intestinal site. To date, nearly 30 other macaques have undergone the intestinal survival surgery, some on more than one occasion, without experiencing any clinical difficulty. Overall, our results suggest that in healthy macaques, intestinal resection survival surgery can be conducted safely. Further, the method can be used to reliably sample the intestinal mucosa without major or persistent impact on humoral or cellular immune responses.

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Section: Introductionmentioning

confidence: 99%