Intestinal lesions in immune deficiency

Eidelman, Shmuel

doi:10.1016/s0046-8177(76)80056-1

Cited by 18 publications

(4 citation statements)

References 81 publications

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“…IgG is therefore probably of little importance for iniesiinal surface defence; this may partly explain ihe preservation of a heailhy gut mucosa in our IgG subclass-deficient piUient.s. This conclusion is in agreetncnt with previous reports on palients with more generalized B cell deficiency (hypogammaglobulinaemia), who showed only minor clinical, functional or structural abnormalilics in ihe gul (Eidelman. 1976;Nils.sen ct at.. 1989), IgG probably plays a more important role at mucosai surfaces in the upper respiratory tract.…”

Section: Discussionsupporting

confidence: 92%

Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies

Nilssen

Söderström

Brandtzæg

et al. 1991

Clinical and Experimental Immunology

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SUMMARY The subclass distribution of IgG‐producing immunocytes was examined by immunohistochemistry in nasal and rectal mucosa of infection‐prone patients with untreated IgG subclass deficiencies. Biopsy specimens from the two sites were obtained in 18 clinically and serologically well‐characterized adult subjects; only a nasal or rectal sample was available from nine similar patients. Chronic lung disease was common in the patient groups with selective serum IgG1 deficiency and combined IgG1 and IgG3 deficiency, whereas the other categories of patients had mainly upper airway and other mild infections. Serum IgG2 or IgG3 deficiency was usually expressed also at the cellular level in rectal mucosa, and the proportion of rectal IgG1 cells was significantly correlated with the IgG1 level (r= 0.90, P < 0.001). Likewise, there tended to be a decreased expression of the actual subclass at the cellular level in nasal mucosa of patients with serum IgG1 or IgG2 deficiency. Conversely, the median nasal proportion of IgG3 celts was remarkably unaffected by a deficiency of this subclass in serum and reclal mucosa. Interestingly, these patients rather tended to have raised IgG3 and reduced IgG2 cell proportions in their nasal mucosa, although this apparent local IgG3 compensation was nevertheless strongly correlated with the serum IgG3 level (r = 0.87, P < 0.002). These disparities may reflect different antigenic and mitogenic exposure of the two tissue sites; for example, a persistent protein bombardment of the nasal mucosa that could conceivably override locally a B cell maturation defect. The possible clinical consequences of such variable mucosal expression of IgG subclass deficiencies remain to be studied.

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Section: Discussionsupporting

confidence: 92%

Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies

Nilssen

Söderström

Brandtzæg

et al. 1991

Clinical and Experimental Immunology

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“…ILNH is primarily a colonoscopic or radiological diagnosis rather than a histopathological diagnosis 9,10 . While an increased number of enlarged lymphoid follicles is seen in the ileum of children with antibody deficiency conditions, 11–13 enlarged lymphoid follicles do not on their own indicate ileal pathology—under the microscope an enlarged lymphoid follicle from a child with antibody deficiency is identical to a lymphoid follicle from a patient without gut inflammation 14 …”

Section: Resultsmentioning

confidence: 99%

Autistic enterocolitis; is it a histopathological entity?

MacDonald¹,

Domizio²

2007

Histopathology

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“…It is still more intriguing that gastrointestinal disorders are quite rare in patients with infantile X-linked (Bruton-type) B cell deficiency leading to agammaglobulinemia (Eidelman, 1976;Ochs and Ament, 1976;Brandtzaeg and Nilssen, 1995;. Conversely, 20-50% of the patients with common variable immunodeficiency (hypogammaglobulinemia) develop diarrhea and malabsorption.…”

Section: Selective Iga Deficiency and Related Clinical Problemsmentioning

confidence: 99%

“…Some patients with hypogammaglobulinemia who present with diarrhea have a markedly increased number of ILFs in their gastrointestinal mucosa, mainly in the small intestine (Eidelman, 1976). These follicles contain a distinct mantle zone of sIgD + IgM + naïve B lymphocytes.…”

Section: Selective Iga Deficiency and Related Clinical Problemsmentioning

confidence: 99%

The Mucosal B Cell System

Brandtzæg

2015

Mucosal Immunology

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Intestinal lesions in immune deficiency

Cited by 18 publications

References 81 publications

Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies

Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies

Autistic enterocolitis; is it a histopathological entity?

The Mucosal B Cell System

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