Intestinal Malabsorption and Immunoglobulin Deficiency

Gelzayd, Eugene A.

doi:10.1001/archinte.1971.00310130145027

Cited by 14 publications

(5 citation statements)

References 32 publications

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“…Several reports of patients with IgA deficiency and coeliac disease have been presented (Crabbe 668 and Heremans, 1967;Hobbs, 1968;Claman et al, 1970;Gelzayd et al, 1971) but the true incidence of this combination is unknown. Since coeliac disease may give rise to very few symptoms in children of over 2 (Visakorpi et al, 1970), we wanted to study the incidence of this disease in IgAdeficient children.…”

Section: Discussionmentioning

confidence: 99%

IgA deficiency in children: A clinical study with special reference to intestinal findings

Savilahti¹,

Pelkonen²,

Visakorpi³

1971

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 99%

IgA deficiency in children: A clinical study with special reference to intestinal findings

Savilahti¹,

Pelkonen²,

Visakorpi³

1971

Archives of Disease in Childhood

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“…It occurs in about one out of 500-700 persons [3,131 and is the most common immunoglobulin deficiency. It is often present without any signs of disease [3,5,7,131, but it may be connected with numerous disorders of different kinds, such as ataxia teleangiectasia, recurrent respiratory tract infections, and malabsorption syndromes [l, 9,191.…”

Section: Introductionmentioning

confidence: 99%

Selective IgA Deficiency in Blood Donors

Koistinen

1975

Vox Sanguinis

160

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The frequency of selective deficiency of serum IgA was determined in a population of 64,588 new Finnish blood donors by Ouchterlony's double diffusion with 10 mug/ml as the limit of detection. The incidence was 1:396. Those found IgA-deficient were retested by hemagglutination inhibition and by radioimmunoassay. The calculated incidences of IgA levels below 0.5 and 0.015 mug/ml were 1:500 and 1:800, respectively. Statistically significant compensatory elevation of serum IgG was observed in the IgA-deficient donors. The IgM levels were not changed. Among 9,920 hospital patients, the incidence of IgA deficiency was 1:660. The age structure of the IgA-deficient patients was similar to that of the IgA-deficient healthy blood donors but lower than that of hospital patients in general. No difference was observed between the clinical history of IgA-deficienct blood donors and of the controls.

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“…Although selective deficiency of IgA occurs in healthy populations [13], it has been reported more often in association with recurrent respiratory tract infections, intestinal disorders, rheumatoid arthritis and other autoimmune diseases [4, 8,10,12,171. Human anti-IgM isoantibodies and antibodies against tissue IgG, human collagen, basement membrane and bovine milk and colostrum may occur in this condition [l, 5, 7, 20, 211.…”

Section: Introductionmentioning

confidence: 99%

Immunological Abnormalities in the Sera of IgA‐Deficient Blood Donors

Koistinen

Sarna

1975

Vox Sanguinis

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Immunological abnormalities of 163 IgA-deficient blood donors were studied. Anti-IgA antibodies were found in 15, anti-IgG antibodies (measured by the Ripley test) in 34, latex test positivity in 21, anti-IgM antibodies in 9 and antibodies against bovine milk in 41 sera. These numbers differed significantly from the control groups of normal blood donors. In the studies of thyroglobulin antibodies, antinuclear antibodies and blood group A and B isoagglutinins there was no difference from the controls. Interrelationships of all findings were studies by statistical analysis. Correlations were found between latex and Ripley tests and rheumatic disorders as well as between high age and anti-IgA antibodies. Male subjects had antibodies against bovine milk more often than females. Otherwise no striking findings were brought up by the statistical analysis.

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Intestinal Malabsorption and Immunoglobulin Deficiency

Cited by 14 publications

References 32 publications

IgA deficiency in children: A clinical study with special reference to intestinal findings

IgA deficiency in children: A clinical study with special reference to intestinal findings

Selective IgA Deficiency in Blood Donors

Immunological Abnormalities in the Sera of IgA‐Deficient Blood Donors

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